A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene

A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene

Abstract Background Polysialic acid (polySia) modifies six cell surface proteins in humans mainly during fetal development and some blood cells in adults. Two genes in humans, ST8SIA2 and ST8SIA4, code for polysialyltransferases that synthesize polySia. ST8SIA2 is highly expressed during fetal devel...

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Bibliographic Details
Main Authors: Gregory R. Moe, Lindsay M. Steirer, Joshua A. Lee, Adarsha Shivakumar, Alejandro D. Bolanos
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glycans
de-N-acetyl polysialic acid
Nucleolin
ST8SIA2
Immune shielding
cancer
Online Access:https://doi.org/10.1186/s13046-021-02099-y

Internet

https://doi.org/10.1186/s13046-021-02099-y

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