Expression Profile of Genes Related to the Th17 Pathway in Macrophages Infected by Leishmania major and Leishmania amazonensis: The Use of Gene Regulatory Networks in Modeling This Pathway

Expression Profile of Genes Related to the Th17 Pathway in Macrophages Infected by Leishmania major and Leishmania amazonensis: The Use of Gene Regulatory Networks in Modeling This Pathway

Leishmania amazonensis and Leishmania major are the causative agents of cutaneous and mucocutaneous diseases. The infections‘ outcome depends on host–parasite interactions and Th1/Th2 response, and in cutaneous form, regulation of Th17 cytokines has been reported to maintain inflammation in lesions....

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Bibliographic Details
Main Authors: Leilane Oliveira Gonçalves, Andrés F. Vallejo Pulido, Fernando Augusto Siqueira Mathias, Alexandre Estevão Silvério Enes, Maria Gabriela Reis Carvalho, Daniela de Melo Resende, Marta E. Polak, Jeronimo C. Ruiz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Leishmania–macrophage interaction
gene regulatory network (GRN)
expression profiling
Th17
immune modulation
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.826523/full

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