Proliferative Verrucous Leukoplakia Revisited: A Retrospective Clinicopathological Study
(1) Objective: To review the criteria proposed by Cerero-Lapiedra et al. and to retrospectively identify the under-diagnosed disease in patients diagnosed with proliferative verrucous leukoplakia. (2) Materials and methods: In this study, we included patients who were diagnosed with leukoplakia (his...
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MDPI AG
2021-06-01
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| Series: | Clinics and Practice |
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| author | Snehashish Ghosh Roopa S. Rao Manoj K. Upadhyay Karuna Kumari D. Sharathkumar Sanketh A. Thirumal Raj Sameena Parveen Yaser Ali Alhazmi Ankur Jethlia Shazia Mushtaq Sachin Sarode Rodolfo Reda Shankargouda Patil Luca Testarelli |
| author_facet | Snehashish Ghosh Roopa S. Rao Manoj K. Upadhyay Karuna Kumari D. Sharathkumar Sanketh A. Thirumal Raj Sameena Parveen Yaser Ali Alhazmi Ankur Jethlia Shazia Mushtaq Sachin Sarode Rodolfo Reda Shankargouda Patil Luca Testarelli |
| author_sort | Snehashish Ghosh |
| collection | DOAJ |
| description | (1) Objective: To review the criteria proposed by Cerero-Lapiedra et al. and to retrospectively identify the under-diagnosed disease in patients diagnosed with proliferative verrucous leukoplakia. (2) Materials and methods: In this study, we included patients who were diagnosed with leukoplakia (histological label consistent with the clinical diagnosis, <i>n</i> = 95), and cases with a final diagnosis within the spectrum of proliferative verrucous leukoplakia (<i>n</i> = 110) as defined by Batsakis et al. We applied the criteria proposed by Cerero-Lepiedra et al. to screen for the possible cases of proliferative verrucous leukoplakia. (3) Results: Although many of our patients satisfied specific isolated criteria, only 11 cases satisfied specific combinations of the guidelines to satisfy a diagnosis of proliferative verrucous leukoplakia. However, due to the lack of follow-up data, the disease is not confirmed in these 11 cases. (4) Conclusion: A limited number of cases of proliferative verrucous leukoplakia were diagnosed using the criteria given by Cerero-Lapiedra et al. The true natural history of the disease could not be studied due to the lack of follow-up data. (5) Clinical relevance: Proliferative verrucous leukoplakia presenting as hyperkeratosis or mild epithelial dysplasia are often not followed up, and they subsequently transform into carcinoma. Thus, clinicians must be vigilant whenever they encounter leukoplakia, especially with multifocal presentations. In such cases, the follow-up data are the key to understanding the true nature of the disease entity. |
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| issn | 2039-7283 |
| language | English |
| last_indexed | 2024-03-10T10:48:48Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-63f97004a58243f7860db542c17777252023-11-21T22:23:00ZengMDPI AGClinics and Practice2039-72832021-06-0111233734610.3390/clinpract11020048Proliferative Verrucous Leukoplakia Revisited: A Retrospective Clinicopathological StudySnehashish Ghosh0Roopa S. Rao1Manoj K. Upadhyay2Karuna Kumari3D. Sharathkumar Sanketh4A. Thirumal Raj5Sameena Parveen6Yaser Ali Alhazmi7Ankur Jethlia8Shazia Mushtaq9Sachin Sarode10Rodolfo Reda11Shankargouda Patil12Luca Testarelli13Department of Oral Pathology, M. B. Kedia Dental College and Teaching Hospital, Birgunj 44300, NepalDepartment of Oral Pathology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore 560054, IndiaDepartment of Conservative Dentistry and Endodontics, M. B. Kedia Dental College and Teaching Hospital, Birgunj 44300, NepalPrivate Dental Practice, Hyderabad 500081, IndiaPrivate Dental Practice, Chennai 600030, IndiaDepartment of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, IndiaDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune 411018, IndiaDepartment of Oral and Maxillofacial Sciences, Sapienza University, University of Rome, 00185 Rome, ItalyDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Oral and Maxillofacial Sciences, Sapienza University, University of Rome, 00185 Rome, Italy(1) Objective: To review the criteria proposed by Cerero-Lapiedra et al. and to retrospectively identify the under-diagnosed disease in patients diagnosed with proliferative verrucous leukoplakia. (2) Materials and methods: In this study, we included patients who were diagnosed with leukoplakia (histological label consistent with the clinical diagnosis, <i>n</i> = 95), and cases with a final diagnosis within the spectrum of proliferative verrucous leukoplakia (<i>n</i> = 110) as defined by Batsakis et al. We applied the criteria proposed by Cerero-Lepiedra et al. to screen for the possible cases of proliferative verrucous leukoplakia. (3) Results: Although many of our patients satisfied specific isolated criteria, only 11 cases satisfied specific combinations of the guidelines to satisfy a diagnosis of proliferative verrucous leukoplakia. However, due to the lack of follow-up data, the disease is not confirmed in these 11 cases. (4) Conclusion: A limited number of cases of proliferative verrucous leukoplakia were diagnosed using the criteria given by Cerero-Lapiedra et al. The true natural history of the disease could not be studied due to the lack of follow-up data. (5) Clinical relevance: Proliferative verrucous leukoplakia presenting as hyperkeratosis or mild epithelial dysplasia are often not followed up, and they subsequently transform into carcinoma. Thus, clinicians must be vigilant whenever they encounter leukoplakia, especially with multifocal presentations. In such cases, the follow-up data are the key to understanding the true nature of the disease entity.https://www.mdpi.com/2039-7283/11/2/48leukoplakiaoral diseaseoral pathologyproliferative verrucous leukoplakia |
| spellingShingle | Snehashish Ghosh Roopa S. Rao Manoj K. Upadhyay Karuna Kumari D. Sharathkumar Sanketh A. Thirumal Raj Sameena Parveen Yaser Ali Alhazmi Ankur Jethlia Shazia Mushtaq Sachin Sarode Rodolfo Reda Shankargouda Patil Luca Testarelli Proliferative Verrucous Leukoplakia Revisited: A Retrospective Clinicopathological Study Clinics and Practice leukoplakia oral disease oral pathology proliferative verrucous leukoplakia |
| title | Proliferative Verrucous Leukoplakia Revisited: A Retrospective Clinicopathological Study |
| title_full | Proliferative Verrucous Leukoplakia Revisited: A Retrospective Clinicopathological Study |
| title_fullStr | Proliferative Verrucous Leukoplakia Revisited: A Retrospective Clinicopathological Study |
| title_full_unstemmed | Proliferative Verrucous Leukoplakia Revisited: A Retrospective Clinicopathological Study |
| title_short | Proliferative Verrucous Leukoplakia Revisited: A Retrospective Clinicopathological Study |
| title_sort | proliferative verrucous leukoplakia revisited a retrospective clinicopathological study |
| topic | leukoplakia oral disease oral pathology proliferative verrucous leukoplakia |
| url | https://www.mdpi.com/2039-7283/11/2/48 |
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