Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
Abstract To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-88786-4 |
| _version_ | 1818754080085901312 |
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| author | Josephine M. Forbes Selena Le Bagge Samuel Righi Amelia K. Fotheringham Linda A. Gallo Domenica A. McCarthy Sherman Leung Tracey Baskerville Janelle Nisbett Adam Morton Stephanie Teasdale Neisha D’Silva Helen Barrett Timothy Jones Jennifer Couper Kim Donaghue Nicole Isbel David W. Johnson Leigh Donnellan Permal Deo Lisa K. Akison Karen M. Moritz Trisha O’Moore-Sullivan |
| author_facet | Josephine M. Forbes Selena Le Bagge Samuel Righi Amelia K. Fotheringham Linda A. Gallo Domenica A. McCarthy Sherman Leung Tracey Baskerville Janelle Nisbett Adam Morton Stephanie Teasdale Neisha D’Silva Helen Barrett Timothy Jones Jennifer Couper Kim Donaghue Nicole Isbel David W. Johnson Leigh Donnellan Permal Deo Lisa K. Akison Karen M. Moritz Trisha O’Moore-Sullivan |
| author_sort | Josephine M. Forbes |
| collection | DOAJ |
| description | Abstract To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/mol; diabetes duration 10.7 ± 5.2 years; BMI 24.5(5.3) kg/m2) and healthy controls (N = 299; 20.3 ± 1.8 years; M:F-83:116; FBG 5.2 ± 0.8 mmol/L; BMI 22.5(3.3) kg/m2) were recruited. Skin autofluorescence (sAF) and circulating AGEs were measured. In a subset of both groups, kidney function was estimated by GFRCKD-EPI CysC and uACR, and DKD risk defined by uACR tertiles. Youth with type 1 diabetes had higher sAF and BMI, and were taller than controls. For sAF, 13.6% of variance was explained by diabetes duration, height and BMI (P model = 1.5 × 10–12). In the sub-set examining kidney function, eGFR and sAF were higher in type 1 diabetes versus controls. eGFR and sAF predicted 24.5% of variance in DKD risk (P model = 2.2 × 10–9), which increased with diabetes duration (51%; P model < 2.2 × 10–16) and random blood glucose concentrations (56%; P model < 2.2 × 10–16). HbA1C and circulating fructosamine albumin were higher in individuals with type 1 diabetes at high versus low DKD risk. eGFR was independently associated with DKD risk in all models. Higher eGFR and longer diabetes duration are associated with DKD risk in youth with type 1 diabetes. sAF, circulating AGEs, and urinary AGEs were not independent predictors of DKD risk. Changes in eGFR should be monitored early, in addition to uACR, for determining DKD risk in type 1 diabetes. |
| first_indexed | 2024-12-18T05:17:34Z |
| format | Article |
| id | doaj.art-63f9c5c97c1c4806aeb2dec23ed2a3a1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T05:17:34Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-63f9c5c97c1c4806aeb2dec23ed2a3a12022-12-21T21:19:44ZengNature PortfolioScientific Reports2045-23222021-05-0111111010.1038/s41598-021-88786-4Advanced glycation end products as predictors of renal function in youth with type 1 diabetesJosephine M. Forbes0Selena Le Bagge1Samuel Righi2Amelia K. Fotheringham3Linda A. Gallo4Domenica A. McCarthy5Sherman Leung6Tracey Baskerville7Janelle Nisbett8Adam Morton9Stephanie Teasdale10Neisha D’Silva11Helen Barrett12Timothy Jones13Jennifer Couper14Kim Donaghue15Nicole Isbel16David W. Johnson17Leigh Donnellan18Permal Deo19Lisa K. Akison20Karen M. Moritz21Trisha O’Moore-Sullivan22Mater Research Institute, The University of Queensland, TRIMater Research Institute, The University of Queensland, TRIMater Research Institute, The University of Queensland, TRIMater Research Institute, The University of Queensland, TRIMater Research Institute, The University of Queensland, TRIMater Research Institute, The University of Queensland, TRIMater Research Institute, The University of Queensland, TRIMater Research Institute, The University of Queensland, TRIMater Young Adults Health Centre, Mater Health ServiceMater Young Adults Health Centre, Mater Health ServiceMater Young Adults Health Centre, Mater Health ServiceMater Young Adults Health Centre, Mater Health ServiceMater Research Institute, The University of Queensland, TRITelethon Kid’s InstituteRobinson Research Institute, University of AdelaideChildren’s Hospital at WestmeadSchool of Biomedical Science and Faculty of Medicine, The University of QueenslandSchool of Biomedical Science and Faculty of Medicine, The University of QueenslandHealth and Biomedical Innovation, UniSA Clinical and Health Sciences, University of South AustraliaHealth and Biomedical Innovation, UniSA Clinical and Health Sciences, University of South AustraliaSchool of Biomedical Science and Faculty of Medicine, The University of QueenslandSchool of Biomedical Science and Faculty of Medicine, The University of QueenslandMater Research Institute, The University of Queensland, TRIAbstract To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/mol; diabetes duration 10.7 ± 5.2 years; BMI 24.5(5.3) kg/m2) and healthy controls (N = 299; 20.3 ± 1.8 years; M:F-83:116; FBG 5.2 ± 0.8 mmol/L; BMI 22.5(3.3) kg/m2) were recruited. Skin autofluorescence (sAF) and circulating AGEs were measured. In a subset of both groups, kidney function was estimated by GFRCKD-EPI CysC and uACR, and DKD risk defined by uACR tertiles. Youth with type 1 diabetes had higher sAF and BMI, and were taller than controls. For sAF, 13.6% of variance was explained by diabetes duration, height and BMI (P model = 1.5 × 10–12). In the sub-set examining kidney function, eGFR and sAF were higher in type 1 diabetes versus controls. eGFR and sAF predicted 24.5% of variance in DKD risk (P model = 2.2 × 10–9), which increased with diabetes duration (51%; P model < 2.2 × 10–16) and random blood glucose concentrations (56%; P model < 2.2 × 10–16). HbA1C and circulating fructosamine albumin were higher in individuals with type 1 diabetes at high versus low DKD risk. eGFR was independently associated with DKD risk in all models. Higher eGFR and longer diabetes duration are associated with DKD risk in youth with type 1 diabetes. sAF, circulating AGEs, and urinary AGEs were not independent predictors of DKD risk. Changes in eGFR should be monitored early, in addition to uACR, for determining DKD risk in type 1 diabetes.https://doi.org/10.1038/s41598-021-88786-4 |
| spellingShingle | Josephine M. Forbes Selena Le Bagge Samuel Righi Amelia K. Fotheringham Linda A. Gallo Domenica A. McCarthy Sherman Leung Tracey Baskerville Janelle Nisbett Adam Morton Stephanie Teasdale Neisha D’Silva Helen Barrett Timothy Jones Jennifer Couper Kim Donaghue Nicole Isbel David W. Johnson Leigh Donnellan Permal Deo Lisa K. Akison Karen M. Moritz Trisha O’Moore-Sullivan Advanced glycation end products as predictors of renal function in youth with type 1 diabetes Scientific Reports |
| title | Advanced glycation end products as predictors of renal function in youth with type 1 diabetes |
| title_full | Advanced glycation end products as predictors of renal function in youth with type 1 diabetes |
| title_fullStr | Advanced glycation end products as predictors of renal function in youth with type 1 diabetes |
| title_full_unstemmed | Advanced glycation end products as predictors of renal function in youth with type 1 diabetes |
| title_short | Advanced glycation end products as predictors of renal function in youth with type 1 diabetes |
| title_sort | advanced glycation end products as predictors of renal function in youth with type 1 diabetes |
| url | https://doi.org/10.1038/s41598-021-88786-4 |
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