Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study
Abstract Background Cytomegalovirus (CMV) infection is a leading cause of morbidity and mortality after transplantation. This study aimed to investigate CMV seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients. Methods The clinical data of the patients who underwent...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-022-07853-x |
| _version_ | 1811187007560351744 |
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| author | Chunrong Ju Xiaohua Wang Xin Xu Shaobo Xie Qingdong Cao Wanli Lin Jianheng Zhang Yu Xu Qiaoyan Lian Danxia Huang Rongchang Chen Jianxing He |
| author_facet | Chunrong Ju Xiaohua Wang Xin Xu Shaobo Xie Qingdong Cao Wanli Lin Jianheng Zhang Yu Xu Qiaoyan Lian Danxia Huang Rongchang Chen Jianxing He |
| author_sort | Chunrong Ju |
| collection | DOAJ |
| description | Abstract Background Cytomegalovirus (CMV) infection is a leading cause of morbidity and mortality after transplantation. This study aimed to investigate CMV seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients. Methods The clinical data of the patients who underwent lung and/or heart transplantation between January 2015 and October 2020 were retrospectively collected from four transplantation centers in China. Results A total of 308 patients were analyzed. The CMV serostatus was donor positive (D+) recipient negative (R−) in 19 (6.17%) patients, D+/R+ in 233 (75.65%), D−/R+ in 36 (11.69%), and D−/R− in 20 (6.50%). CMV DNAemia was detected in 52.3% of the patients and tissue-invasive CMV disease was diagnosed in 16.2% of the patients. Only 31.8% of the patients adhered to the postdischarge valganciclovir therapy. The D+/R− serostatus (odds ratio [OR]: 18.32; 95% confidence interval [CI]:1.80-188.68), no valganciclovir prophylaxis (OR: 2.64; 95% CI: 1.05–6.64), and higher doses of rabbit anti-human thymocyte globulin (> 2 mg/kg) (OR: 4.25; 95% CI: 1.92–9.42) were risk factors of CMV disease. Conclusion CMV seroprevalence was high in Chinese thoracic organ transplant donors and recipients. The low adherence rate to the postdischarge CMV prophylaxis therapy in Chinese patients is still an unresolved issue. |
| first_indexed | 2024-04-11T13:54:58Z |
| format | Article |
| id | doaj.art-63fa800390e84693b9d46b1b564b2123 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-11T13:54:58Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-63fa800390e84693b9d46b1b564b21232022-12-22T04:20:22ZengBMCBMC Infectious Diseases1471-23342022-11-012211710.1186/s12879-022-07853-xCytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort studyChunrong Ju0Xiaohua Wang1Xin Xu2Shaobo Xie3Qingdong Cao4Wanli Lin5Jianheng Zhang6Yu Xu7Qiaoyan Lian8Danxia Huang9Rongchang Chen10Jianxing He11Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Thoracic Surgery and Lung Transplantation, Fifth Affiliated Hospital of Sun Yat-sen UniversityDepartment of Thoracic Surgery, The People’s Hospital of GaozhouGuangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityShenzhen People’s Hospital Institute of Respiratory Diseases, Southern University of Science and Technology, University of Jinan Second Clinical Medical CollegeGuangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityAbstract Background Cytomegalovirus (CMV) infection is a leading cause of morbidity and mortality after transplantation. This study aimed to investigate CMV seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients. Methods The clinical data of the patients who underwent lung and/or heart transplantation between January 2015 and October 2020 were retrospectively collected from four transplantation centers in China. Results A total of 308 patients were analyzed. The CMV serostatus was donor positive (D+) recipient negative (R−) in 19 (6.17%) patients, D+/R+ in 233 (75.65%), D−/R+ in 36 (11.69%), and D−/R− in 20 (6.50%). CMV DNAemia was detected in 52.3% of the patients and tissue-invasive CMV disease was diagnosed in 16.2% of the patients. Only 31.8% of the patients adhered to the postdischarge valganciclovir therapy. The D+/R− serostatus (odds ratio [OR]: 18.32; 95% confidence interval [CI]:1.80-188.68), no valganciclovir prophylaxis (OR: 2.64; 95% CI: 1.05–6.64), and higher doses of rabbit anti-human thymocyte globulin (> 2 mg/kg) (OR: 4.25; 95% CI: 1.92–9.42) were risk factors of CMV disease. Conclusion CMV seroprevalence was high in Chinese thoracic organ transplant donors and recipients. The low adherence rate to the postdischarge CMV prophylaxis therapy in Chinese patients is still an unresolved issue.https://doi.org/10.1186/s12879-022-07853-xCytomegalovirusThoracic organ transplantValganciclovirPneumoniaSeroprevalence |
| spellingShingle | Chunrong Ju Xiaohua Wang Xin Xu Shaobo Xie Qingdong Cao Wanli Lin Jianheng Zhang Yu Xu Qiaoyan Lian Danxia Huang Rongchang Chen Jianxing He Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study BMC Infectious Diseases Cytomegalovirus Thoracic organ transplant Valganciclovir Pneumonia Seroprevalence |
| title | Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study |
| title_full | Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study |
| title_fullStr | Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study |
| title_full_unstemmed | Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study |
| title_short | Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study |
| title_sort | cytomegalovirus seroprevalence infection and disease in chinese thoracic organ transplant recipients a retrospective cohort study |
| topic | Cytomegalovirus Thoracic organ transplant Valganciclovir Pneumonia Seroprevalence |
| url | https://doi.org/10.1186/s12879-022-07853-x |
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