Summary: | A new method for the synthesis of α-trifluoromethylated tertiary alcohols bearing coumarins is described. The reaction of 3-(trifluoroacetyl)coumarin and pyrrole provided the target compounds with high yields under catalyst-free, mild conditions. The crystal structure of compound <b>3fa</b> was investigated by X-ray diffraction analysis. The biological activities, such as in vitro antifungal activity of the α-trifluoromethylated tertiary alcohols against Fusarium graminearum, Fusarium oxysporum, Fusarium moniliforme, Rhizoctonia solani Kuhn, and Phytophthora parasitica var nicotianae, were investigated. The bioassay results indicated that compounds <b>3ad</b>, <b>3gd</b>, and <b>3hd</b> showed broad-spectrum antifungal activity in vitro. Compound <b>3cd</b> exhibited excellent fungicidal activity against Rhizoctonia solani Kuhn, with an EC<sub>50</sub> value of 10.9 μg/mL, which was comparable to that of commercial fungicidal triadimefon (EC<sub>50</sub> = 6.1 μg/mL). Furthermore, molecular docking study suggested that <b>3cd</b> had high binding affinities with 1W9U, like argifin.
|