Design, Catalyst-Free Synthesis of New Novel α-Trifluoromethylated Tertiary Alcohols Bearing Coumarins as Potential Antifungal Agents

Design, Catalyst-Free Synthesis of New Novel α-Trifluoromethylated Tertiary Alcohols Bearing Coumarins as Potential Antifungal Agents

A new method for the synthesis of α-trifluoromethylated tertiary alcohols bearing coumarins is described. The reaction of 3-(trifluoroacetyl)coumarin and pyrrole provided the target compounds with high yields under catalyst-free, mild conditions. The crystal structure of compound <b>3fa</b&...

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Bibliographic Details
Main Authors: Shengfei Jiang, Guoyu Yang, Lijun Shi, Liangxin Fan, Zhenliang Pan, Caixia Wang, Xiaodan Chang, Bingyi Zhou, Meng Xu, Lulu Wu, Cuilian Xu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
α-trifluoromethylated tertiary alcohol
coumarin
catalyst-free
antifungal activity
Online Access:https://www.mdpi.com/1420-3049/28/1/260

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