Melatonin attenuates the oxidative injury of smoking rat carotid arteries
Objective To investigate the effect of melatonin on oxidative injury of rat carotid arteries after balloon injury. Methods Twenty male sprague-dawley rats were randomized into control, melatonin, smoking, and smoking plus melatonin. An established protocol of smoking was carried out. The carotid art...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2020-04-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a190750.pdf |
| _version_ | 1797365719271211008 |
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| author | YANG Gen-huan, WANG Yan, LIAO Peng-zhi, JIA Yu-long |
| author_facet | YANG Gen-huan, WANG Yan, LIAO Peng-zhi, JIA Yu-long |
| author_sort | YANG Gen-huan, WANG Yan, LIAO Peng-zhi, JIA Yu-long |
| collection | DOAJ |
| description | Objective To investigate the effect of melatonin on oxidative injury of rat carotid arteries after balloon injury. Methods Twenty male sprague-dawley rats were randomized into control, melatonin, smoking, and smoking plus melatonin. An established protocol of smoking was carried out. The carotid arteries were collected 7 days later. The average content of ROS was measured. And Western blot was used to detected the expression of NF-κB, MCP-1, VCAM-1 and ICAM-1. Results Smoking significantly induced the increase of ROS and the expression of NF-κB, MCP-1, VCAM-1 and ICAM-1 in rat carotid arteries. Moreover, cigarette smoke exposure inhibited the expression of eNOS. Melatonin minimized the effect resulted from smoking. Conclusions Melatonin may attenuate the the oxidative injury and the expression of inflammatory mediators in rat carotid arteries resulted from smoking. |
| first_indexed | 2024-03-08T16:52:58Z |
| format | Article |
| id | doaj.art-63fefa2664df4afc9909ba5e21b1531c |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:52:58Z |
| publishDate | 2020-04-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-63fefa2664df4afc9909ba5e21b1531c2024-01-05T03:14:34ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252020-04-01404528531Melatonin attenuates the oxidative injury of smoking rat carotid arteriesYANG Gen-huan, WANG Yan, LIAO Peng-zhi, JIA Yu-long0Department of Vascular Surgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100070, ChinaObjective To investigate the effect of melatonin on oxidative injury of rat carotid arteries after balloon injury. Methods Twenty male sprague-dawley rats were randomized into control, melatonin, smoking, and smoking plus melatonin. An established protocol of smoking was carried out. The carotid arteries were collected 7 days later. The average content of ROS was measured. And Western blot was used to detected the expression of NF-κB, MCP-1, VCAM-1 and ICAM-1. Results Smoking significantly induced the increase of ROS and the expression of NF-κB, MCP-1, VCAM-1 and ICAM-1 in rat carotid arteries. Moreover, cigarette smoke exposure inhibited the expression of eNOS. Melatonin minimized the effect resulted from smoking. Conclusions Melatonin may attenuate the the oxidative injury and the expression of inflammatory mediators in rat carotid arteries resulted from smoking.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a190750.pdfmelatonin|smoking|oxidative injury|carotid artery |
| spellingShingle | YANG Gen-huan, WANG Yan, LIAO Peng-zhi, JIA Yu-long Melatonin attenuates the oxidative injury of smoking rat carotid arteries Jichu yixue yu linchuang melatonin|smoking|oxidative injury|carotid artery |
| title | Melatonin attenuates the oxidative injury of smoking rat carotid arteries |
| title_full | Melatonin attenuates the oxidative injury of smoking rat carotid arteries |
| title_fullStr | Melatonin attenuates the oxidative injury of smoking rat carotid arteries |
| title_full_unstemmed | Melatonin attenuates the oxidative injury of smoking rat carotid arteries |
| title_short | Melatonin attenuates the oxidative injury of smoking rat carotid arteries |
| title_sort | melatonin attenuates the oxidative injury of smoking rat carotid arteries |
| topic | melatonin|smoking|oxidative injury|carotid artery |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a190750.pdf |
| work_keys_str_mv | AT yanggenhuanwangyanliaopengzhijiayulong melatoninattenuatestheoxidativeinjuryofsmokingratcarotidarteries |