Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction.

Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction.

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Orcinol glucoside (OG), mainly found in the rhizome of the traditional Chinese herb Curculigo orchioides Gaertn, is noted for its antidepressant effects. In this study, an efficient screening pipeline was established for identifying the highly active orcinol synthase (ORS) and UDP-dependent glycosyl...

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Bibliographic Details
Main Authors: Bihuan Chen, Xiaonan Liu, Yina Wang, Jie Bai, Xiangyu Liu, Guisheng Xiang, Wei Liu, Xiaoxi Zhu, Jian Cheng, Lina Lu, Guanghui Zhang, Ge Zhang, Zongjie Dai, Shuhui Zi, Shengchao Yang, Huifeng Jiang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002131

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