Mice experimental model of diabetes mellitus type ii based on high fat diet
An experimental model of the obesity and type II diabetes mellitus formation in C57BL/6 mice using a high fat diet was developed and tested. In the study, it was shown that mice feeding high-fat diet had a significant body weight gain during the 3rd week. By the end of the experiment, body weight ha...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2019-10-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/2399 |
| _version_ | 1797872828095135744 |
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| author | L. V. Kapilevich A. N. Zakharova E. Yu. Dyakova T. A. Kironenko K. G. Milovanova J. G. Kalinnikova A. V. Chibalin |
| author_facet | L. V. Kapilevich A. N. Zakharova E. Yu. Dyakova T. A. Kironenko K. G. Milovanova J. G. Kalinnikova A. V. Chibalin |
| author_sort | L. V. Kapilevich |
| collection | DOAJ |
| description | An experimental model of the obesity and type II diabetes mellitus formation in C57BL/6 mice using a high fat diet was developed and tested. In the study, it was shown that mice feeding high-fat diet had a significant body weight gain during the 3rd week. By the end of the experiment, body weight has more than doubled. In mice that feed chow diet, body weight increased by 50%, by the end of the experiment It was shown that high fat diet also induced glucose tolerance, and the insulin concentration tripled. The data obtained confirm the adequacy of the experimental model of diabetes mellitus type II in mice. |
| first_indexed | 2024-04-10T01:06:21Z |
| format | Article |
| id | doaj.art-6400b55829a345f49db0b163ae3a68b2 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:06:21Z |
| publishDate | 2019-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-6400b55829a345f49db0b163ae3a68b22023-03-13T09:58:25ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842019-10-01183536110.20538/1682-0363-2019-3-53-611538Mice experimental model of diabetes mellitus type ii based on high fat dietL. V. Kapilevich0A. N. Zakharova1E. Yu. Dyakova2T. A. Kironenko3K. G. Milovanova4J. G. Kalinnikova5A. V. Chibalin6Национальный исследовательский Томский государственный университет (НИ ТГУ); Сибирский государственный медицинский университет (СибГМУ)Национальный исследовательский Томский государственный университет (НИ ТГУ)Национальный исследовательский Томский государственный университет (НИ ТГУ)Национальный исследовательский Томский государственный университет (НИ ТГУ)Национальный исследовательский Томский государственный университет (НИ ТГУ)Национальный исследовательский Томский государственный университет (НИ ТГУ)Национальный исследовательский Томский государственный университет (НИ ТГУ); Karolinska InstitutetAn experimental model of the obesity and type II diabetes mellitus formation in C57BL/6 mice using a high fat diet was developed and tested. In the study, it was shown that mice feeding high-fat diet had a significant body weight gain during the 3rd week. By the end of the experiment, body weight has more than doubled. In mice that feed chow diet, body weight increased by 50%, by the end of the experiment It was shown that high fat diet also induced glucose tolerance, and the insulin concentration tripled. The data obtained confirm the adequacy of the experimental model of diabetes mellitus type II in mice.https://bulletin.ssmu.ru/jour/article/view/2399сахарный диабет ii типамодель сахарного диабетажировая диетаинсулинорезистентностьгипергликемия |
| spellingShingle | L. V. Kapilevich A. N. Zakharova E. Yu. Dyakova T. A. Kironenko K. G. Milovanova J. G. Kalinnikova A. V. Chibalin Mice experimental model of diabetes mellitus type ii based on high fat diet Бюллетень сибирской медицины сахарный диабет ii типа модель сахарного диабета жировая диета инсулинорезистентность гипергликемия |
| title | Mice experimental model of diabetes mellitus type ii based on high fat diet |
| title_full | Mice experimental model of diabetes mellitus type ii based on high fat diet |
| title_fullStr | Mice experimental model of diabetes mellitus type ii based on high fat diet |
| title_full_unstemmed | Mice experimental model of diabetes mellitus type ii based on high fat diet |
| title_short | Mice experimental model of diabetes mellitus type ii based on high fat diet |
| title_sort | mice experimental model of diabetes mellitus type ii based on high fat diet |
| topic | сахарный диабет ii типа модель сахарного диабета жировая диета инсулинорезистентность гипергликемия |
| url | https://bulletin.ssmu.ru/jour/article/view/2399 |
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