Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers
Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-11-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | https://www.mdpi.com/2218-0532/87/4/33 |
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| author | Ádám Haimhoffer Ágnes Rusznyák Katalin Réti-Nagy Gábor Vasvári Judit Váradi Miklós Vecsernyés Ildikó Bácskay Pálma Fehér Zoltán Ujhelyi Ferenc Fenyvesi |
| author_facet | Ádám Haimhoffer Ágnes Rusznyák Katalin Réti-Nagy Gábor Vasvári Judit Váradi Miklós Vecsernyés Ildikó Bácskay Pálma Fehér Zoltán Ujhelyi Ferenc Fenyvesi |
| author_sort | Ádám Haimhoffer |
| collection | DOAJ |
| description | Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have several applications in the pharmaceutical field like solubility enhancers or the building blocks of larger drug delivery systems. On the other hand, they have numerous effects on cells or biological barriers. In this review the most important properties of cyclodextrins and cyclodextrin-based drug delivery systems are summarized with special focus on their biological activity. |
| first_indexed | 2024-04-14T01:28:10Z |
| format | Article |
| id | doaj.art-6400e819a0b049ff87a04c09aac99436 |
| institution | Directory Open Access Journal |
| issn | 2218-0532 |
| language | English |
| last_indexed | 2024-04-14T01:28:10Z |
| publishDate | 2019-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-6400e819a0b049ff87a04c09aac994362022-12-22T02:20:20ZengMDPI AGScientia Pharmaceutica2218-05322019-11-018743310.3390/scipharm87040033scipharm87040033Cyclodextrins in Drug Delivery Systems and their Effects on Biological BarriersÁdám Haimhoffer0Ágnes Rusznyák1Katalin Réti-Nagy2Gábor Vasvári3Judit Váradi4Miklós Vecsernyés5Ildikó Bácskay6Pálma Fehér7Zoltán Ujhelyi8Ferenc Fenyvesi9Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, HungaryCyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have several applications in the pharmaceutical field like solubility enhancers or the building blocks of larger drug delivery systems. On the other hand, they have numerous effects on cells or biological barriers. In this review the most important properties of cyclodextrins and cyclodextrin-based drug delivery systems are summarized with special focus on their biological activity.https://www.mdpi.com/2218-0532/87/4/33cyclodextrinsdrug delivery systemsbiological barriersnanopharmaceutics |
| spellingShingle | Ádám Haimhoffer Ágnes Rusznyák Katalin Réti-Nagy Gábor Vasvári Judit Váradi Miklós Vecsernyés Ildikó Bácskay Pálma Fehér Zoltán Ujhelyi Ferenc Fenyvesi Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers Scientia Pharmaceutica cyclodextrins drug delivery systems biological barriers nanopharmaceutics |
| title | Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers |
| title_full | Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers |
| title_fullStr | Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers |
| title_full_unstemmed | Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers |
| title_short | Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers |
| title_sort | cyclodextrins in drug delivery systems and their effects on biological barriers |
| topic | cyclodextrins drug delivery systems biological barriers nanopharmaceutics |
| url | https://www.mdpi.com/2218-0532/87/4/33 |
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