Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats

Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats

Exposure to sedative/hypnotic and anesthetic drugs, such as ketamine, during the critical period of synaptogenesis, causes profound neurotoxicity in the developing rodent and primate brains and is associated with poor cognitive outcomes later in life. The subiculum is especially vulnerable to acute...

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Bibliographic Details
Main Authors: Francesca M. Manzella, Srdjan M. Joksimovic, James E. Orfila, Brier R. Fine, Robert M. Dietz, Dayalan Sampath, Hanna K. Fiedler, Vesna Tesic, Navya Atluri, Yogendra H. Raol, Vesna Jevtovic-Todorovic, Paco S. Herson, Slobodan M. Todorovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Systems Neuroscience
Subjects:
ketamine
sedation
brain development
EEG
long-term potentiation
Online Access:https://www.frontiersin.org/article/10.3389/fnsys.2020.00026/full

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