Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse

Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse

<p>Abstract</p> <p>Background</p> <p>Several lines of evidence indicate that memory loss represents a synaptic failure caused by soluble amyloid β (Aβ) oligomers. However, the pathological relevance of Aβ oligomers (AβOs) as the trigger of synaptic or neuronal degenerat...

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Main Authors: Yamamoto Naoki, Urisu Tsuneo, Abe Koji, Sun Hui, Nabeshima Toshitaka, Mouri Akihiko, Yokoseki Tatsuki, Shibata Masao, Kawarabayashi Takeshi, Okamoto Yasuhide, Takamura Ayumi, Shoji Mikio, Yanagisawa Katsuhiko, Michikawa Makoto, Matsubara Etsuro
Format: Article
Language:English
Published: BMC 2011-03-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/6/1/20

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