Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity

Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity

Here, we developed a novel oncolytic vaccinia virus (NOV) with the dual advantages of cancer selectivity and normal vessel reconstructive activity by replacing the viral thymidine kinase (vTk) and vaccinia growth factor (VGF) genes with genes encoding TNF-related apoptosis-inducing ligand (TRAIL) an...

Full description

Bibliographic Details
Main Authors:	Su-Nam Jeong, So Young Yoo
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Series:	Cancers
Subjects:	oncolytic virus angiopoietin 1 TRAIL
Online Access:	https://www.mdpi.com/2072-6694/12/5/1070

Similar Items

Oncolytic viro-chemotherapy exhibits antitumor effect in laryngeal squamous cell carcinoma cells and mouse xenografts
by: Wang Y, et al.
Published: (2019-04-01)

Monitoring the Efficacy of Oncolytic Viruses via Gene Expression
by: Ashley Ansel, et al.
Published: (2017-11-01)

Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective
by: Palaniyandi Muthukutty, et al.
Published: (2023-07-01)

Oncolytic viruses as anticancer vaccines
by: Norman eWoller, et al.
Published: (2014-07-01)

Oncolytic virus immunotherapy: future prospects for oncology
by: Junaid Raja, et al.
Published: (2018-12-01)

Tumor Tropism of DNA Viruses for Oncolytic Virotherapy
by: Junior A. Enow, et al.
Published: (2023-11-01)

Oncolytic Virus-Induced Autophagy in Glioblastoma
by: Margarita Kamynina, et al.
Published: (2021-07-01)

Past, Present and Future of Oncolytic Reovirus
by: Louise Müller, et al.
Published: (2020-10-01)

Recent progress in combination therapy of oncolytic vaccinia virus
by: Seyedeh Nasim Mirbahari, et al.
Published: (2024-03-01)

Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review
by: Xiangxiang Shao, et al.
Published: (2023-01-01)

Oncolytic Viruses: Therapeutics With an Identity Crisis
by: Caroline J. Breitbach, et al.
Published: (2016-07-01)

Oncolytic Vaccinia Virus in Lung Cancer Vaccines
by: Cao-Sang Truong, et al.
Published: (2022-02-01)

Prospects for Using Expression Patterns of Paramyxovirus Receptors as Biomarkers for Oncolytic Virotherapy
by: Olga V. Matveeva, et al.
Published: (2020-12-01)

Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects
by: Henglong Hu, et al.
Published: (2022-11-01)

Preclinical and clinical trials of oncolytic vaccinia virus in cancer immunotherapy: a comprehensive review
by: Mengyuan Li, et al.
Published: (2023-09-01)

Oncolytic Virotherapy in Glioma Tumors
by: Sergio Rius-Rocabert, et al.
Published: (2020-10-01)

Oncolytic viruses and pancreatic cancer
by: Vahideh Hamidi-Sofiani, et al.
Published: (2022-01-01)

Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy
by: Masmudur M. Rahman, et al.
Published: (2021-10-01)

Genetic Modifications That Expand Oncolytic Virus Potency
by: Francisca Cristi, et al.
Published: (2022-01-01)

Perspectives on immunotherapy via oncolytic viruses
by: Alberto Reale, et al.
Published: (2019-02-01)

From Benchtop to Bedside: A Review of Oncolytic Virotherapy
by: Audrey H. Choi, et al.
Published: (2016-08-01)

Measles to the Rescue: A Review of Oncolytic Measles Virus
by: Sarah Aref, et al.
Published: (2016-10-01)

The Evolution and Future of Targeted Cancer Therapy: From Nanoparticles, Oncolytic Viruses, and Oncolytic Bacteria to the Treatment of Solid Tumors
by: Kyle M. Pierce, et al.
Published: (2021-11-01)

Bovine pestivirus is a new alternative virus for multiple myeloma oncolytic virotherapy
by: Valentina Marchica, et al.
Published: (2020-07-01)

Efficacy and safety of oncolytic virus combined with chemotherapy or immune checkpoint inhibitors in solid tumor patients: A meta-analysis
by: Xiangxing Liu, et al.
Published: (2022-11-01)

A practical guide to the handling and administration of personalized transcriptionally attenuated oncolytic adenoviruses (PTAVs)
by: Christopher Larson, et al.
Published: (2018-09-01)

Deletion of immunomodulatory genes as a novel approach to oncolytic vaccinia virus development
by: Tiffany Y. Ho, et al.
Published: (2021-09-01)

Targeting Autophagy for Oncolytic Immunotherapy
by: Lulu Hu, et al.
Published: (2017-01-01)

Oncolytic virotherapy evolved into the fourth generation as tumor immunotherapy
by: Xianwang Wang, et al.
Published: (2023-07-01)

The Present Status of Immuno-Oncolytic Viruses in the Treatment of Pancreatic Cancer
by: Scott D. Haller, et al.
Published: (2020-11-01)

Clinical Application of Oncolytic Viruses: A Systematic Review
by: Mary Cook, et al.
Published: (2020-10-01)

Advances in oncolytic herpes simplex virus and adenovirus therapy for recurrent glioma
by: Mingming Hu, et al.
Published: (2023-11-01)

Immunomodulatory Arming Factors—The Current Paradigm for Oncolytic Vectors Relies on Immune Stimulating Molecules
by: Cole W. D. Peters, et al.
Published: (2021-08-01)

The combination therapy of oncolytic HSV-1 armed with anti-PD-1 antibody and IL-12 enhances anti-tumor efficacy
by: Xin Xie, et al.
Published: (2022-01-01)

Oncolytic viruses in melanoma
by: Camille Robinson, et al.
Published: (2022-02-01)

Overcoming Tumor Resistance to Oncolyticvaccinia Virus with Anti-PD-1-Based Combination Therapy by Inducing Antitumor Immunity in the Tumor Microenvironment
by: So Young Yoo, et al.
Published: (2020-06-01)

Adenovirus as a Vector and Oncolytic Virus
by: Wataru Matsunaga, et al.
Published: (2023-06-01)

Immunotherapeutic Potential of Oncolytic Vaccinia Virus
by: Stephen eThorne
Published: (2014-06-01)

The Oncolytic Virus in Cancer Diagnosis and Treatment
by: Guo-dong Cao, et al.
Published: (2020-09-01)

Oncolytic herpes simplex virus and immunotherapy
by: Wenqing Ma, et al.
Published: (2018-12-01)