Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center
Abstract Background Brain metastases (BM) are a common complication in advanced cancer patients, and extremely challenging to treat. Consequently, whole brain radiotherapy (WBRT) remains the standard palliative intervention for patients with BM. The present study set to evaluate the clinical benefit...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11675-8 |
| _version_ | 1827581574122569728 |
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| author | Bolanle Adegboyega Adedayo Joseph Adewumi Alabi John Omomila Lindokuhle M. Ngema Victoria Ainsworth Jennifer Chin Moses O Evbuomwan Wilfred Ngwa |
| author_facet | Bolanle Adegboyega Adedayo Joseph Adewumi Alabi John Omomila Lindokuhle M. Ngema Victoria Ainsworth Jennifer Chin Moses O Evbuomwan Wilfred Ngwa |
| author_sort | Bolanle Adegboyega |
| collection | DOAJ |
| description | Abstract Background Brain metastases (BM) are a common complication in advanced cancer patients, and extremely challenging to treat. Consequently, whole brain radiotherapy (WBRT) remains the standard palliative intervention for patients with BM. The present study set to evaluate the clinical benefits of WBRT by assessing the quality of life (QoL) in WBRT-treated patients with BM, in Nigeria. Methods This was a prospective, longitudinal, hospital-based single-centre study. Consecutive sampling methodology was used to recruit 52 patients with BM undergoing WBRT. Patients were followed up on days 7, 30, 90 and 180 after WBRT. The EORTC QLQ-C15-PAL and EORTC QLQ-BN20 were employed to report patients’ responses. The likert scale responses were linearly converted into 0 – 100 scores, and the descriptive analysis was conducted using IBM SPSS Statistics 29.0, at 95% confidence interval, using the two-tailed t-test for continuous variables or the chi-square test for categorical values. The overall survival was calculated with the Kaplan Maier method and the difference tested with Log-rank method, considering the interval from the baseline until death or end of the study. Results The study cohort was predominantly females (82.7%), and accordingly, 65.4% of the respondents had a breast primary tumor. A goodness-of-fit test yielded non-significant Chi square Pearson (p = 0.325) and Deviance (p = 1.000) residuals, indicating the best fit. The median overall survival was 180 days (~ 6 months). A total of 20 patients (38%) that survived up to 180 days reported alleviated symptoms and better functioning. A significant improvement in physical functioning (p < 0.001) and emotional functioning (p = 0.031) was reported at 180 days post WBRT, compared to baseline. Conclusions WBRT is an effective palliative intervention in patients with BM, resulting in improved QoL. More than 50% of patients that survived ~ 3 months reported alleviation of pain, and 38% of patients that survived for ~ 6 months reported a significantly improved functioning. This demonstrated the clinical benefits of WBRT in palliative care and will add to the body of data on the use of WBRT, from Africa. |
| first_indexed | 2024-03-08T22:38:22Z |
| format | Article |
| id | doaj.art-64020fb71ccf4447b758ebadb6c9d7f5 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-08T22:38:22Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-64020fb71ccf4447b758ebadb6c9d7f52023-12-17T12:20:21ZengBMCBMC Cancer1471-24072023-12-0123111010.1186/s12885-023-11675-8Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer CenterBolanle Adegboyega0Adedayo Joseph1Adewumi Alabi2John Omomila3Lindokuhle M. Ngema4Victoria Ainsworth5Jennifer Chin6Moses O Evbuomwan7Wilfred Ngwa8NSIA-LUTH Cancer Center, Lagos University Teaching HospitalNSIA-LUTH Cancer Center, Lagos University Teaching HospitalNSIA-LUTH Cancer Center, Lagos University Teaching HospitalNSIA-LUTH Cancer Center, Lagos University Teaching HospitalJohns Hopkins Medicine, Sydney Kimmel Comprehensive Cancer CentreJohns Hopkins Medicine, Sydney Kimmel Comprehensive Cancer CentreJohns Hopkins Medicine, Sydney Kimmel Comprehensive Cancer CentreUniversity of Iowa Hospitals and Clinics USJohns Hopkins Medicine, Sydney Kimmel Comprehensive Cancer CentreAbstract Background Brain metastases (BM) are a common complication in advanced cancer patients, and extremely challenging to treat. Consequently, whole brain radiotherapy (WBRT) remains the standard palliative intervention for patients with BM. The present study set to evaluate the clinical benefits of WBRT by assessing the quality of life (QoL) in WBRT-treated patients with BM, in Nigeria. Methods This was a prospective, longitudinal, hospital-based single-centre study. Consecutive sampling methodology was used to recruit 52 patients with BM undergoing WBRT. Patients were followed up on days 7, 30, 90 and 180 after WBRT. The EORTC QLQ-C15-PAL and EORTC QLQ-BN20 were employed to report patients’ responses. The likert scale responses were linearly converted into 0 – 100 scores, and the descriptive analysis was conducted using IBM SPSS Statistics 29.0, at 95% confidence interval, using the two-tailed t-test for continuous variables or the chi-square test for categorical values. The overall survival was calculated with the Kaplan Maier method and the difference tested with Log-rank method, considering the interval from the baseline until death or end of the study. Results The study cohort was predominantly females (82.7%), and accordingly, 65.4% of the respondents had a breast primary tumor. A goodness-of-fit test yielded non-significant Chi square Pearson (p = 0.325) and Deviance (p = 1.000) residuals, indicating the best fit. The median overall survival was 180 days (~ 6 months). A total of 20 patients (38%) that survived up to 180 days reported alleviated symptoms and better functioning. A significant improvement in physical functioning (p < 0.001) and emotional functioning (p = 0.031) was reported at 180 days post WBRT, compared to baseline. Conclusions WBRT is an effective palliative intervention in patients with BM, resulting in improved QoL. More than 50% of patients that survived ~ 3 months reported alleviation of pain, and 38% of patients that survived for ~ 6 months reported a significantly improved functioning. This demonstrated the clinical benefits of WBRT in palliative care and will add to the body of data on the use of WBRT, from Africa.https://doi.org/10.1186/s12885-023-11675-8Brain metastasesWhole-brain radiotherapyQuality of lifePatient reported outcomes |
| spellingShingle | Bolanle Adegboyega Adedayo Joseph Adewumi Alabi John Omomila Lindokuhle M. Ngema Victoria Ainsworth Jennifer Chin Moses O Evbuomwan Wilfred Ngwa Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center BMC Cancer Brain metastases Whole-brain radiotherapy Quality of life Patient reported outcomes |
| title | Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center |
| title_full | Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center |
| title_fullStr | Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center |
| title_full_unstemmed | Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center |
| title_short | Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center |
| title_sort | patient reported outcomes following whole brain radiotherapy in patients with brain metastases in nsia luth cancer center |
| topic | Brain metastases Whole-brain radiotherapy Quality of life Patient reported outcomes |
| url | https://doi.org/10.1186/s12885-023-11675-8 |
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