Peripheral Blood CD8+T Cell as a Prognostic Biomarker for Hospitalised COVID-19 Patients Without Antiviral Treatment
Yuming Sun,1– 6,* Peilin Liu,7,* Lifang Zhang,8 Shaorong Lei,1 Qian Gao7 1Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2National Engineering Research Centre of Personalized Diagnostic and Therapeutic Tec...
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| Format: | Article |
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Dove Medical Press
2024-01-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/peripheral-blood-cd8t-cell-as-a-prognostic-biomarker-for-hospitalised--peer-reviewed-fulltext-article-IDR |
| _version_ | 1797357144136220672 |
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| author | Sun Y Liu P Zhang L Lei S Gao Q |
| author_facet | Sun Y Liu P Zhang L Lei S Gao Q |
| author_sort | Sun Y |
| collection | DOAJ |
| description | Yuming Sun,1– 6,* Peilin Liu,7,* Lifang Zhang,8 Shaorong Lei,1 Qian Gao7 1Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2National Engineering Research Centre of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 3Furong Laboratory, Central South University, Changsha, People’s Republic of China; 4Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Centre of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 5National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 6Department of Dermatology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 7Clinical Laboratory Department, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 8Department of Plastic and Cosmetic Surgery, Changsha Mylike Cosmetic Hospital, Changsha, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian Gao; Shaorong Lei, Email gaoqian@csu.edu.cn; leishaorong@csu.edu.cnBackground: The status of T lymphocyte subset counts in patients with COVID-19 remains uncertain. This study aimed to assess alterations in peripheral blood CD3+CD8+T (CD8+T) cells among hospitalized COVID-19 patients who have not received antiviral treatment and to evaluate their prognostic value within this patient population.Methods: A single-center, retrospective cohort study and a meta-analysis were conducted. The cohort study was performed at Xiangya Hospital from December 5, 2022, to January 31, 2023. We conducted a meta-analysis to explore the association between peripheral blood CD3+CD8+T cells and mortality in COVID-19 patients who did not receive antiviral therapy. All relevant studies in Embase, PubMed, Web of Science databases were systematically searched for meta-analysis.Results: The retrospective cohort study included 201 patients. A significant decrease in peripheral blood CD8+ T cell count was found to be associated with an increased risk of mortality (adjusted odds ratio [aOR]: 13.88; 95% confidence interval [CI]: 3.15– 61.23), after adjusting for gender, age, comorbidities, severity at admission, steroid therapy, and antibiotic therapy. The threshold value for CD8+T cell counts, determined by the receiver operating characteristic (ROC) curve analysis, was 145.5 (area under the curve [AUC]: 0.828, specificity: 90.3%, sensitivity: 72.9%, P< 0.001). Additionally, A total of 7 studies with 2765 participants were included in the meta-analysis. The meta-analysis reveals a significant association between lower CD8+ T cell counts and mortality (odds ratio [OR] = 3.543, 95% CI: 1.726 to 7.272; I2=93%).Conclusion: Peripheral blood CD8+ T cell can serve as a valuable prognostic biomarker for hospitalized patients who do not receive antiviral treatment.Keywords: peripheral blood CD3+CD8+T cell, prognostic biomarker, hospitalised COVID-19 patients |
| first_indexed | 2024-03-08T14:40:41Z |
| format | Article |
| id | doaj.art-64034a8781244fdfadba6de65b0c15d6 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-08T14:40:41Z |
| publishDate | 2024-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-64034a8781244fdfadba6de65b0c15d62024-01-11T18:05:55ZengDove Medical PressInfection and Drug Resistance1178-69732024-01-01Volume 1710911789660Peripheral Blood CD8+T Cell as a Prognostic Biomarker for Hospitalised COVID-19 Patients Without Antiviral TreatmentSun YLiu PZhang LLei SGao QYuming Sun,1– 6,* Peilin Liu,7,* Lifang Zhang,8 Shaorong Lei,1 Qian Gao7 1Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2National Engineering Research Centre of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 3Furong Laboratory, Central South University, Changsha, People’s Republic of China; 4Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Centre of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 5National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 6Department of Dermatology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 7Clinical Laboratory Department, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 8Department of Plastic and Cosmetic Surgery, Changsha Mylike Cosmetic Hospital, Changsha, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian Gao; Shaorong Lei, Email gaoqian@csu.edu.cn; leishaorong@csu.edu.cnBackground: The status of T lymphocyte subset counts in patients with COVID-19 remains uncertain. This study aimed to assess alterations in peripheral blood CD3+CD8+T (CD8+T) cells among hospitalized COVID-19 patients who have not received antiviral treatment and to evaluate their prognostic value within this patient population.Methods: A single-center, retrospective cohort study and a meta-analysis were conducted. The cohort study was performed at Xiangya Hospital from December 5, 2022, to January 31, 2023. We conducted a meta-analysis to explore the association between peripheral blood CD3+CD8+T cells and mortality in COVID-19 patients who did not receive antiviral therapy. All relevant studies in Embase, PubMed, Web of Science databases were systematically searched for meta-analysis.Results: The retrospective cohort study included 201 patients. A significant decrease in peripheral blood CD8+ T cell count was found to be associated with an increased risk of mortality (adjusted odds ratio [aOR]: 13.88; 95% confidence interval [CI]: 3.15– 61.23), after adjusting for gender, age, comorbidities, severity at admission, steroid therapy, and antibiotic therapy. The threshold value for CD8+T cell counts, determined by the receiver operating characteristic (ROC) curve analysis, was 145.5 (area under the curve [AUC]: 0.828, specificity: 90.3%, sensitivity: 72.9%, P< 0.001). Additionally, A total of 7 studies with 2765 participants were included in the meta-analysis. The meta-analysis reveals a significant association between lower CD8+ T cell counts and mortality (odds ratio [OR] = 3.543, 95% CI: 1.726 to 7.272; I2=93%).Conclusion: Peripheral blood CD8+ T cell can serve as a valuable prognostic biomarker for hospitalized patients who do not receive antiviral treatment.Keywords: peripheral blood CD3+CD8+T cell, prognostic biomarker, hospitalised COVID-19 patientshttps://www.dovepress.com/peripheral-blood-cd8t-cell-as-a-prognostic-biomarker-for-hospitalised--peer-reviewed-fulltext-article-IDRperipheral blood cd3+cd8+t cellprognostic biomarkerhospitalised covid-19 patients |
| spellingShingle | Sun Y Liu P Zhang L Lei S Gao Q Peripheral Blood CD8+T Cell as a Prognostic Biomarker for Hospitalised COVID-19 Patients Without Antiviral Treatment Infection and Drug Resistance peripheral blood cd3+cd8+t cell prognostic biomarker hospitalised covid-19 patients |
| title | Peripheral Blood CD8+T Cell as a Prognostic Biomarker for Hospitalised COVID-19 Patients Without Antiviral Treatment |
| title_full | Peripheral Blood CD8+T Cell as a Prognostic Biomarker for Hospitalised COVID-19 Patients Without Antiviral Treatment |
| title_fullStr | Peripheral Blood CD8+T Cell as a Prognostic Biomarker for Hospitalised COVID-19 Patients Without Antiviral Treatment |
| title_full_unstemmed | Peripheral Blood CD8+T Cell as a Prognostic Biomarker for Hospitalised COVID-19 Patients Without Antiviral Treatment |
| title_short | Peripheral Blood CD8+T Cell as a Prognostic Biomarker for Hospitalised COVID-19 Patients Without Antiviral Treatment |
| title_sort | peripheral blood cd8 t cell as a prognostic biomarker for hospitalised covid 19 patients without antiviral treatment |
| topic | peripheral blood cd3+cd8+t cell prognostic biomarker hospitalised covid-19 patients |
| url | https://www.dovepress.com/peripheral-blood-cd8t-cell-as-a-prognostic-biomarker-for-hospitalised--peer-reviewed-fulltext-article-IDR |
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