Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy
Cystic trophoblastic tumor (CTT) is a rare testicular germ cell tumor (GCT) predominantly seen in post-chemotherapy patients. It is prognostically similar to teratoma and requires no additional chemotherapy in the absence of a nonteratomatous GCT component. We report a case of metastatic CTT in a pa...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | Urology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214442017300852 |
| _version_ | 1818256750728445952 |
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| author | Michael L. Wang Jonathan B. McHugh Alon Z. Weizer Todd M. Morgan Arul M. Chinnaiyan Andrew P. Sciallis Amir Lagstein Daniel E. Spratt Rohit Mehra |
| author_facet | Michael L. Wang Jonathan B. McHugh Alon Z. Weizer Todd M. Morgan Arul M. Chinnaiyan Andrew P. Sciallis Amir Lagstein Daniel E. Spratt Rohit Mehra |
| author_sort | Michael L. Wang |
| collection | DOAJ |
| description | Cystic trophoblastic tumor (CTT) is a rare testicular germ cell tumor (GCT) predominantly seen in post-chemotherapy patients. It is prognostically similar to teratoma and requires no additional chemotherapy in the absence of a nonteratomatous GCT component. We report a case of metastatic CTT in a patient with primary testicular teratoma without prior chemotherapy. Retroperitoneal lymph node metastases contained teratoma, embryonal carcinoma, and CTT. The CTT was β-hCG positive and SALL4 negative by immunohistochemistry (IHC). CTT can arise in metastatic testicular GCT in treatment naïve patients. An important differential diagnosis is choriocarcinoma due to treatment implications, and SALL4 IHC may help. |
| first_indexed | 2024-12-12T17:32:43Z |
| format | Article |
| id | doaj.art-640399eadfcc49ca9712a9f85ecbba2b |
| institution | Directory Open Access Journal |
| issn | 2214-4420 |
| language | English |
| last_indexed | 2024-12-12T17:32:43Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Urology Case Reports |
| spelling | doaj.art-640399eadfcc49ca9712a9f85ecbba2b2022-12-22T00:17:19ZengElsevierUrology Case Reports2214-44202017-07-0113C15415710.1016/j.eucr.2017.04.014Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior ChemotherapyMichael L. Wang0Jonathan B. McHugh1Alon Z. Weizer2Todd M. Morgan3Arul M. Chinnaiyan4Andrew P. Sciallis5Amir Lagstein6Daniel E. Spratt7Rohit Mehra8Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USADepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USADepartment of Urology, University of Michigan Medical School, Ann Arbor, MI, USADepartment of Urology, University of Michigan Medical School, Ann Arbor, MI, USADepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USADepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USADepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USADepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USADepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USACystic trophoblastic tumor (CTT) is a rare testicular germ cell tumor (GCT) predominantly seen in post-chemotherapy patients. It is prognostically similar to teratoma and requires no additional chemotherapy in the absence of a nonteratomatous GCT component. We report a case of metastatic CTT in a patient with primary testicular teratoma without prior chemotherapy. Retroperitoneal lymph node metastases contained teratoma, embryonal carcinoma, and CTT. The CTT was β-hCG positive and SALL4 negative by immunohistochemistry (IHC). CTT can arise in metastatic testicular GCT in treatment naïve patients. An important differential diagnosis is choriocarcinoma due to treatment implications, and SALL4 IHC may help.http://www.sciencedirect.com/science/article/pii/S2214442017300852Testicular germ cell tumorCystic trophoblastic tumorChoriocarcinomaSALL4 |
| spellingShingle | Michael L. Wang Jonathan B. McHugh Alon Z. Weizer Todd M. Morgan Arul M. Chinnaiyan Andrew P. Sciallis Amir Lagstein Daniel E. Spratt Rohit Mehra Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy Urology Case Reports Testicular germ cell tumor Cystic trophoblastic tumor Choriocarcinoma SALL4 |
| title | Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy |
| title_full | Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy |
| title_fullStr | Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy |
| title_full_unstemmed | Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy |
| title_short | Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy |
| title_sort | rare presentation of metastatic cystic trophoblastic tumor in a patient without prior chemotherapy |
| topic | Testicular germ cell tumor Cystic trophoblastic tumor Choriocarcinoma SALL4 |
| url | http://www.sciencedirect.com/science/article/pii/S2214442017300852 |
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