Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies
The anti-oxidant effects of melatonin and the immune-pineal axis are well established. However, how they play a role in the pathogenesis of neurodegenerative diseases is not well elucidated. A better understanding of this neuro-immuno-endocrinological link can help in the development of novel therap...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844018368014 |
| _version_ | 1818408568068505600 |
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| author | Nitya Beriwal Tashi Namgyal Pema Sangay Asmaa Monther Al Quraan |
| author_facet | Nitya Beriwal Tashi Namgyal Pema Sangay Asmaa Monther Al Quraan |
| author_sort | Nitya Beriwal |
| collection | DOAJ |
| description | The anti-oxidant effects of melatonin and the immune-pineal axis are well established. However, how they play a role in the pathogenesis of neurodegenerative diseases is not well elucidated. A better understanding of this neuro-immuno-endocrinological link can help in the development of novel therapies with higher efficacy to alleviate symptomatology, slow disease progression and improve the quality of life. Recent studies have shown that the immune-pineal axis acts as an immunological buffer, neurohormonal switch and it also intricately links the pathogenesis of neurodegenerative diseases (like Multiple sclerosis, Alzheimer's disease, Parkinson's disease) and inflammation at a molecular level. Furthermore, alteration in circadian melatonin production is seen in neurodegenerative diseases. This review will summarise the mechanics by which the immune-pineal axis and neuro-immuno-endocrinological disturbances affect the pathogenesis and progression of neurodegenerative diseases. It will also explore, how this understanding will help in the development of novel hybrid melatonin hormone therapies for the treatment of neurodegenerative diseases. |
| first_indexed | 2024-12-14T09:45:48Z |
| format | Article |
| id | doaj.art-6405d0b669224b3dbebc177f401caf18 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-14T09:45:48Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-6405d0b669224b3dbebc177f401caf182022-12-21T23:07:39ZengElsevierHeliyon2405-84402019-01-0151e01190Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapiesNitya Beriwal0Tashi Namgyal1Pema Sangay2Asmaa Monther Al Quraan3Corresponding author. Lady Hardinge Medical College, New Delhi, India.; Department of Research, California Institute of Behavioral Neurosciences and Psychology, 4751, Mangels Boulevard, Fairfield, 94534, CA, USADepartment of Research, California Institute of Behavioral Neurosciences and Psychology, 4751, Mangels Boulevard, Fairfield, 94534, CA, USADepartment of Research, California Institute of Behavioral Neurosciences and Psychology, 4751, Mangels Boulevard, Fairfield, 94534, CA, USADepartment of Research, California Institute of Behavioral Neurosciences and Psychology, 4751, Mangels Boulevard, Fairfield, 94534, CA, USAThe anti-oxidant effects of melatonin and the immune-pineal axis are well established. However, how they play a role in the pathogenesis of neurodegenerative diseases is not well elucidated. A better understanding of this neuro-immuno-endocrinological link can help in the development of novel therapies with higher efficacy to alleviate symptomatology, slow disease progression and improve the quality of life. Recent studies have shown that the immune-pineal axis acts as an immunological buffer, neurohormonal switch and it also intricately links the pathogenesis of neurodegenerative diseases (like Multiple sclerosis, Alzheimer's disease, Parkinson's disease) and inflammation at a molecular level. Furthermore, alteration in circadian melatonin production is seen in neurodegenerative diseases. This review will summarise the mechanics by which the immune-pineal axis and neuro-immuno-endocrinological disturbances affect the pathogenesis and progression of neurodegenerative diseases. It will also explore, how this understanding will help in the development of novel hybrid melatonin hormone therapies for the treatment of neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S2405844018368014NeurosciencePhysiologyPharmaceutical science |
| spellingShingle | Nitya Beriwal Tashi Namgyal Pema Sangay Asmaa Monther Al Quraan Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies Heliyon Neuroscience Physiology Pharmaceutical science |
| title | Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies |
| title_full | Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies |
| title_fullStr | Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies |
| title_full_unstemmed | Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies |
| title_short | Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies |
| title_sort | role of immune pineal axis in neurodegenerative diseases unraveling novel hybrid dark hormone therapies |
| topic | Neuroscience Physiology Pharmaceutical science |
| url | http://www.sciencedirect.com/science/article/pii/S2405844018368014 |
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