Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin
Osmotin is a stress responsive antifungal protein belonging to the pathogenesis-related (PR)-5 family that confers tolerance to both biotic and abiotic stresses in plants. Protective efforts of osmotin in plants range from high temperature to cold and salt to drought. It lyses the plasma membrane of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-03-01
|
| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpls.2015.00163/full |
| _version_ | 1818365369535954944 |
|---|---|
| author | S. eANIL KUMAR P. eHIMA KUMARI G. eSHRAVAN KUMAR C. eMOHANALATHA P. B. KAVI KISHOR |
| author_facet | S. eANIL KUMAR P. eHIMA KUMARI G. eSHRAVAN KUMAR C. eMOHANALATHA P. B. KAVI KISHOR |
| author_sort | S. eANIL KUMAR |
| collection | DOAJ |
| description | Osmotin is a stress responsive antifungal protein belonging to the pathogenesis-related (PR)-5 family that confers tolerance to both biotic and abiotic stresses in plants. Protective efforts of osmotin in plants range from high temperature to cold and salt to drought. It lyses the plasma membrane of the pathogens. It is widely distributed in fruits and vegetables. It is a differentially expressed and developmentally regulated protein that protects the cells from osmotic stress and invading pathogens as well, by structural or metabolic alterations. During stress conditions, osmotin helps in the accumulation of the osmolyte proline, which quenches reactive oxygen species and free radicals. Osmotin expression results in the accumulation of storage reserves and increases the shelf-life of fruits. It binds to a seven-transmembrane-domain receptor-like protein and induces programmed cell death in Saccharomyces cerevisiae through RAS2/cAMP signaling pathway. Adiponectin, produced in adipose tissues of mammals, is an insulin-sensitizing hormone. Strangely, osmotin acts like the mammalian hormone adiponectin in various in vitro and in vivo models. Adiponectin and osmotin, the two receptor binding proteins do not share sequence similarity at the amino acid level, but interestingly they have a similar structural and functional properties. In experimental mice, adiponectin inhibits endothelial cell proliferation and migration, primary tumor growth, and reduces atherosclerosis. This retrospective work examines the vital role of osmotin in plant defense and as a potential targeted therapeutic drug for humans. |
| first_indexed | 2024-12-13T22:19:10Z |
| format | Article |
| id | doaj.art-6406188f39d54326a642b7d1e7651d5f |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-13T22:19:10Z |
| publishDate | 2015-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-6406188f39d54326a642b7d1e7651d5f2022-12-21T23:29:25ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2015-03-01610.3389/fpls.2015.00163104576Osmotin: a plant sentinel and a possible agonist of mammalian adiponectinS. eANIL KUMAR0P. eHIMA KUMARI1G. eSHRAVAN KUMAR2C. eMOHANALATHA3P. B. KAVI KISHOR4OSMANIA UNIVERSITYOSMANIA UNIVERSITYOSMANIA UNIVERSITYBIOCLUESOSMANIA UNIVERSITYOsmotin is a stress responsive antifungal protein belonging to the pathogenesis-related (PR)-5 family that confers tolerance to both biotic and abiotic stresses in plants. Protective efforts of osmotin in plants range from high temperature to cold and salt to drought. It lyses the plasma membrane of the pathogens. It is widely distributed in fruits and vegetables. It is a differentially expressed and developmentally regulated protein that protects the cells from osmotic stress and invading pathogens as well, by structural or metabolic alterations. During stress conditions, osmotin helps in the accumulation of the osmolyte proline, which quenches reactive oxygen species and free radicals. Osmotin expression results in the accumulation of storage reserves and increases the shelf-life of fruits. It binds to a seven-transmembrane-domain receptor-like protein and induces programmed cell death in Saccharomyces cerevisiae through RAS2/cAMP signaling pathway. Adiponectin, produced in adipose tissues of mammals, is an insulin-sensitizing hormone. Strangely, osmotin acts like the mammalian hormone adiponectin in various in vitro and in vivo models. Adiponectin and osmotin, the two receptor binding proteins do not share sequence similarity at the amino acid level, but interestingly they have a similar structural and functional properties. In experimental mice, adiponectin inhibits endothelial cell proliferation and migration, primary tumor growth, and reduces atherosclerosis. This retrospective work examines the vital role of osmotin in plant defense and as a potential targeted therapeutic drug for humans.http://journal.frontiersin.org/Journal/10.3389/fpls.2015.00163/fullAdiponectinabiotic stressbiotic stressprotein-protein interactionsOLPsosmotin |
| spellingShingle | S. eANIL KUMAR P. eHIMA KUMARI G. eSHRAVAN KUMAR C. eMOHANALATHA P. B. KAVI KISHOR Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin Frontiers in Plant Science Adiponectin abiotic stress biotic stress protein-protein interactions OLPs osmotin |
| title | Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin |
| title_full | Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin |
| title_fullStr | Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin |
| title_full_unstemmed | Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin |
| title_short | Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin |
| title_sort | osmotin a plant sentinel and a possible agonist of mammalian adiponectin |
| topic | Adiponectin abiotic stress biotic stress protein-protein interactions OLPs osmotin |
| url | http://journal.frontiersin.org/Journal/10.3389/fpls.2015.00163/full |
| work_keys_str_mv | AT seanilkumar osmotinaplantsentinelandapossibleagonistofmammalianadiponectin AT pehimakumari osmotinaplantsentinelandapossibleagonistofmammalianadiponectin AT geshravankumar osmotinaplantsentinelandapossibleagonistofmammalianadiponectin AT cemohanalatha osmotinaplantsentinelandapossibleagonistofmammalianadiponectin AT pbkavikishor osmotinaplantsentinelandapossibleagonistofmammalianadiponectin |