Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1
<p>Abstract</p> <p>Background</p> <p>It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals, and one of the signs of aging is progressive gonadal dysfunction.</p> <p>Methods</p> <p>To study the effects of i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-07-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | http://www.ovarianresearch.com/content/5/1/18 |
| _version_ | 1797963847923924992 |
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| author | Słuczanowska-Głąbowska Sylwia Laszczyńska Maria Piotrowska Katarzyna Głąbowski Wojciech Kopchick John J Bartke Andrzej Kucia Magda Ratajczak Mariusz Z |
| author_facet | Słuczanowska-Głąbowska Sylwia Laszczyńska Maria Piotrowska Katarzyna Głąbowski Wojciech Kopchick John J Bartke Andrzej Kucia Magda Ratajczak Mariusz Z |
| author_sort | Słuczanowska-Głąbowska Sylwia |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals, and one of the signs of aging is progressive gonadal dysfunction.</p> <p>Methods</p> <p>To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on ovaries, we analyzed ovaries isolated from 2-year-old growth hormone receptor knockout (GHR-KO) Laron dwarf mice, with low circulating plasma levels of IGF-1, and 6-month-old bovine growth hormone transgenic (bGHTg) mice, with high circulating plasma levels of IGF-1. The ages of the Laron dwarf mutants employed in our studies were selected based on their overall survival (up to <sub>~</sub> 4 years for Laron dwarf mice and <sub>~</sub> 1 year for bGHTg mice).</p> <p>Results</p> <p>Morphological analysis of the ovaries of mice that reached <sub>~</sub>50% of their maximal life span revealed a lower biological age for the ovaries isolated from 2-year-old Laron dwarf mice than their normal-lifespan wild type littermates. By contrast, the ovarian morphology of increased in size 6 month old bGHTg mice was generally normal.</p> <p>Conclusion</p> <p>Ovaries isolated from 2-year-old Laron dwarf mice exhibit a lower biological age compared with ovaries from normal WT littermates at the same age. At the same time, no morphological features of accelerated aging were found in 0.5-year-old bGHTg mice compared with ovaries from normal the same age-matched WT littermates.</p> |
| first_indexed | 2024-04-11T01:34:44Z |
| format | Article |
| id | doaj.art-640852bc56314184bf75aa6196a5c98f |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T01:34:44Z |
| publishDate | 2012-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-640852bc56314184bf75aa6196a5c98f2023-01-03T09:03:25ZengBMCJournal of Ovarian Research1757-22152012-07-01511810.1186/1757-2215-5-18Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1Słuczanowska-Głąbowska SylwiaLaszczyńska MariaPiotrowska KatarzynaGłąbowski WojciechKopchick John JBartke AndrzejKucia MagdaRatajczak Mariusz Z<p>Abstract</p> <p>Background</p> <p>It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals, and one of the signs of aging is progressive gonadal dysfunction.</p> <p>Methods</p> <p>To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on ovaries, we analyzed ovaries isolated from 2-year-old growth hormone receptor knockout (GHR-KO) Laron dwarf mice, with low circulating plasma levels of IGF-1, and 6-month-old bovine growth hormone transgenic (bGHTg) mice, with high circulating plasma levels of IGF-1. The ages of the Laron dwarf mutants employed in our studies were selected based on their overall survival (up to <sub>~</sub> 4 years for Laron dwarf mice and <sub>~</sub> 1 year for bGHTg mice).</p> <p>Results</p> <p>Morphological analysis of the ovaries of mice that reached <sub>~</sub>50% of their maximal life span revealed a lower biological age for the ovaries isolated from 2-year-old Laron dwarf mice than their normal-lifespan wild type littermates. By contrast, the ovarian morphology of increased in size 6 month old bGHTg mice was generally normal.</p> <p>Conclusion</p> <p>Ovaries isolated from 2-year-old Laron dwarf mice exhibit a lower biological age compared with ovaries from normal WT littermates at the same age. At the same time, no morphological features of accelerated aging were found in 0.5-year-old bGHTg mice compared with ovaries from normal the same age-matched WT littermates.</p>http://www.ovarianresearch.com/content/5/1/18Murine ovaryLaron dwarf mouseBovine growth hormone transgenic mouseGrowth hormoneInsulin-like growth factor-1Aging |
| spellingShingle | Słuczanowska-Głąbowska Sylwia Laszczyńska Maria Piotrowska Katarzyna Głąbowski Wojciech Kopchick John J Bartke Andrzej Kucia Magda Ratajczak Mariusz Z Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1 Journal of Ovarian Research Murine ovary Laron dwarf mouse Bovine growth hormone transgenic mouse Growth hormone Insulin-like growth factor-1 Aging |
| title | Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1 |
| title_full | Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1 |
| title_fullStr | Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1 |
| title_full_unstemmed | Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1 |
| title_short | Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1 |
| title_sort | morphology of ovaries in laron dwarf mice with low circulating plasma levels of insulin like growth factor 1 igf 1 and in bovine gh transgenic mice with high circulating plasma levels of igf 1 |
| topic | Murine ovary Laron dwarf mouse Bovine growth hormone transgenic mouse Growth hormone Insulin-like growth factor-1 Aging |
| url | http://www.ovarianresearch.com/content/5/1/18 |
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