Hippocampal and Cortical Pyramidal Neurons Swell in Parallel with Astrocytes during Acute Hypoosmolar Stress

Hippocampal and Cortical Pyramidal Neurons Swell in Parallel with Astrocytes during Acute Hypoosmolar Stress

Normal nervous system function is critically dependent on the balance of water and ions in the extracellular space (ECS). Pathological reduction in brain interstitial osmolarity results in osmotically-driven flux of water into cells, causing cellular edema which reduces the ECS and increases neurona...

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Bibliographic Details
Main Authors: Thomas R. Murphy, David Davila, Nicholas Cuvelier, Leslie R. Young, Kelli Lauderdale, Devin K. Binder, Todd A. Fiacco
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hypoosmolar
cellular edema
AQP4
neuronal swelling
cell volume
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00275/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00275/full

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