Dihydrotestosterone ameliorates degeneration in muscle, axons and motoneurons and improves motor function in amyotrophic lateral sclerosis model mice.
Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by a progressive loss of motoneurons. The clinical symptoms include skeletal muscle weakness and atrophy, which impairs motor performance and eventually leads to respiratory failure. We tested whether dihydrotestosterone (DHT), wh...
Main Authors: | Young-Eun Yoo, Chien-Ping Ko |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3351454?pdf=render |
Similar Items
-
Dihydrotestosterone in Amyotrophic lateral sclerosis—The missing link?
by: Nishit Sawal, et al.
Published: (2020-11-01) -
How Degeneration of Cells Surrounding Motoneurons Contributes to Amyotrophic Lateral Sclerosis
by: Roxane Crabé, et al.
Published: (2020-11-01) -
F Wave Study in Amyotrophic Lateral Sclerosis: Assessment of Segmental Motoneuronal Dysfunction
by: Jia Fang, et al.
Published: (2015-01-01) -
Acute retigabine‐induced effects on myelinated motor axons in amyotrophic lateral sclerosis
by: Boudewijn T. H. M. Sleutjes, et al.
Published: (2022-08-01) -
Brain imaging signatures in amyotrophic lateral sclerosis: Correlation with peripheral motor degeneration
by: Sung‐Ju Hsueh, et al.
Published: (2023-08-01)