A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury
The growth plate cartilage supports long bone growth. Here the authors identify FoxA2+ long term stem cells in the growth plate that are stratified with short term PTHrP+ cells, participate in production of hyaline cartilage, expand in response to trauma, and whose ablation impairs cartilage regener...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30247-1 |
| _version_ | 1811307945784246272 |
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| author | Shanmugam Muruganandan Rachel Pierce Dian Astari Teguh Rocio Fuente Perez Nicole Bell Brandon Nguyen Katherine Hohl Brian D. Snyder Mark W. Grinstaff Hannah Alberico Dori Woods Yiwei Kong Corneliu Sima Sanket Bhagat Kailing Ho Vicki Rosen Laura Gamer Andreia M. Ionescu |
| author_facet | Shanmugam Muruganandan Rachel Pierce Dian Astari Teguh Rocio Fuente Perez Nicole Bell Brandon Nguyen Katherine Hohl Brian D. Snyder Mark W. Grinstaff Hannah Alberico Dori Woods Yiwei Kong Corneliu Sima Sanket Bhagat Kailing Ho Vicki Rosen Laura Gamer Andreia M. Ionescu |
| author_sort | Shanmugam Muruganandan |
| collection | DOAJ |
| description | The growth plate cartilage supports long bone growth. Here the authors identify FoxA2+ long term stem cells in the growth plate that are stratified with short term PTHrP+ cells, participate in production of hyaline cartilage, expand in response to trauma, and whose ablation impairs cartilage regeneration. |
| first_indexed | 2024-04-13T09:13:23Z |
| format | Article |
| id | doaj.art-640d916cf4354cb5856b093525dfb60f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T09:13:23Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-640d916cf4354cb5856b093525dfb60f2022-12-22T02:52:48ZengNature PortfolioNature Communications2041-17232022-05-0113111510.1038/s41467-022-30247-1A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injuryShanmugam Muruganandan0Rachel Pierce1Dian Astari Teguh2Rocio Fuente Perez3Nicole Bell4Brandon Nguyen5Katherine Hohl6Brian D. Snyder7Mark W. Grinstaff8Hannah Alberico9Dori Woods10Yiwei Kong11Corneliu Sima12Sanket Bhagat13Kailing Ho14Vicki Rosen15Laura Gamer16Andreia M. Ionescu17Department of Biology, 134 Mugar Life Sciences Building, Northeastern UniversityDepartment of Biology, 134 Mugar Life Sciences Building, Northeastern UniversityCentre for Advanced Orthopedic Studies, Beth Israel Deaconess Medical CenterDivision of Pediatrics, University of OviedoNew York University College of DentistryModerna TherapeuticsCentre for Advanced Orthopedic Studies, Beth Israel Deaconess Medical CenterDepartment of Orthopedic Surgery, Boston Children’s HospitalDepartments of Biomedical Engineering, Chemistry, and Medicine, Boston UniversityDepartment of Biology, 134 Mugar Life Sciences Building, Northeastern UniversityDepartment of Biology, 134 Mugar Life Sciences Building, Northeastern UniversityDepartment of Biology, 134 Mugar Life Sciences Building, Northeastern UniversityDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental MedicineUltragenyx PharmaceuticalDepartment of Developmental Biology, Harvard School of Dental MedicineDepartment of Developmental Biology, Harvard School of Dental MedicineDepartment of Developmental Biology, Harvard School of Dental MedicineDepartment of Biology, 134 Mugar Life Sciences Building, Northeastern UniversityThe growth plate cartilage supports long bone growth. Here the authors identify FoxA2+ long term stem cells in the growth plate that are stratified with short term PTHrP+ cells, participate in production of hyaline cartilage, expand in response to trauma, and whose ablation impairs cartilage regeneration.https://doi.org/10.1038/s41467-022-30247-1 |
| spellingShingle | Shanmugam Muruganandan Rachel Pierce Dian Astari Teguh Rocio Fuente Perez Nicole Bell Brandon Nguyen Katherine Hohl Brian D. Snyder Mark W. Grinstaff Hannah Alberico Dori Woods Yiwei Kong Corneliu Sima Sanket Bhagat Kailing Ho Vicki Rosen Laura Gamer Andreia M. Ionescu A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury Nature Communications |
| title | A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury |
| title_full | A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury |
| title_fullStr | A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury |
| title_full_unstemmed | A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury |
| title_short | A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury |
| title_sort | foxa2 long term stem cell population is necessary for growth plate cartilage regeneration after injury |
| url | https://doi.org/10.1038/s41467-022-30247-1 |
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