A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury

A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury

The growth plate cartilage supports long bone growth. Here the authors identify FoxA2+ long term stem cells in the growth plate that are stratified with short term PTHrP+ cells, participate in production of hyaline cartilage, expand in response to trauma, and whose ablation impairs cartilage regener...

Full description

Bibliographic Details
Main Authors: Shanmugam Muruganandan, Rachel Pierce, Dian Astari Teguh, Rocio Fuente Perez, Nicole Bell, Brandon Nguyen, Katherine Hohl, Brian D. Snyder, Mark W. Grinstaff, Hannah Alberico, Dori Woods, Yiwei Kong, Corneliu Sima, Sanket Bhagat, Kailing Ho, Vicki Rosen, Laura Gamer, Andreia M. Ionescu
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30247-1

Similar Items

Similar Items