Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors
The metabotropic glutamate receptors (mGluRs) form a family of neuromodulatory G-protein-coupled receptors that contain both a seven-helix transmembrane domain (TMD) and a large extracellular ligand-binding domain (LBD) which enables stable dimerization. Although numerous studies have revealed varia...
Main Authors: | Jordana K Thibado, Jean-Yves Tano, Joon Lee, Leslie Salas-Estrada, Davide Provasi, Alexa Strauss, Joao Marcelo Lamim Ribeiro, Guoqing Xiang, Johannes Broichhagen, Marta Filizola, Martin J Lohse, Joshua Levitz |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/67027 |
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