Understanding False Negative in Prenatal Testing
A false negative can happen in many kinds of medical tests, regardless of whether they are screening or diagnostic in nature. However, it inevitably poses serious concerns especially in a prenatal setting because its sequelae can mark the birth of an affected child beyond expectation. False negative...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/11/5/888 |
| _version_ | 1797533816376524800 |
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| author | Mark I. Evans Ming Chen David W. Britt |
| author_facet | Mark I. Evans Ming Chen David W. Britt |
| author_sort | Mark I. Evans |
| collection | DOAJ |
| description | A false negative can happen in many kinds of medical tests, regardless of whether they are screening or diagnostic in nature. However, it inevitably poses serious concerns especially in a prenatal setting because its sequelae can mark the birth of an affected child beyond expectation. False negatives are not a new thing because of emerging new tests in the field of reproductive, especially prenatal, genetics but has occurred throughout the evolution of prenatal screening and diagnosis programs. In this paper we aim to discuss the basic differences between screening and diagnosis, the trade-offs and the choices, and also shed light on the crucial points clinicians need to know and be aware of so that a quality service can be provided in a coherent and sensible way to patients so that vital issues related to a false negative result can be appropriately comprehended by all parties. |
| first_indexed | 2024-03-10T11:19:59Z |
| format | Article |
| id | doaj.art-641273c3435c43b694017706ccdd87fb |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T11:19:59Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-641273c3435c43b694017706ccdd87fb2023-11-21T20:05:29ZengMDPI AGDiagnostics2075-44182021-05-0111588810.3390/diagnostics11050888Understanding False Negative in Prenatal TestingMark I. Evans0Ming Chen1David W. Britt2Fetal Medicine Foundation of America, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USADepartment of Genomic Medicine, Changhua Christian Hospital, Changhua 50046, TaiwanFetal Medicine Foundation of America, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USAA false negative can happen in many kinds of medical tests, regardless of whether they are screening or diagnostic in nature. However, it inevitably poses serious concerns especially in a prenatal setting because its sequelae can mark the birth of an affected child beyond expectation. False negatives are not a new thing because of emerging new tests in the field of reproductive, especially prenatal, genetics but has occurred throughout the evolution of prenatal screening and diagnosis programs. In this paper we aim to discuss the basic differences between screening and diagnosis, the trade-offs and the choices, and also shed light on the crucial points clinicians need to know and be aware of so that a quality service can be provided in a coherent and sensible way to patients so that vital issues related to a false negative result can be appropriately comprehended by all parties.https://www.mdpi.com/2075-4418/11/5/888down syndrome screeningnoninvasive prenatal testingmicroarrayneural tube defectmendelian screening panel |
| spellingShingle | Mark I. Evans Ming Chen David W. Britt Understanding False Negative in Prenatal Testing Diagnostics down syndrome screening noninvasive prenatal testing microarray neural tube defect mendelian screening panel |
| title | Understanding False Negative in Prenatal Testing |
| title_full | Understanding False Negative in Prenatal Testing |
| title_fullStr | Understanding False Negative in Prenatal Testing |
| title_full_unstemmed | Understanding False Negative in Prenatal Testing |
| title_short | Understanding False Negative in Prenatal Testing |
| title_sort | understanding false negative in prenatal testing |
| topic | down syndrome screening noninvasive prenatal testing microarray neural tube defect mendelian screening panel |
| url | https://www.mdpi.com/2075-4418/11/5/888 |
| work_keys_str_mv | AT markievans understandingfalsenegativeinprenataltesting AT mingchen understandingfalsenegativeinprenataltesting AT davidwbritt understandingfalsenegativeinprenataltesting |