MICRONUTRIENTS AND CHILDREN'S PHYSICAL GROWTH: A META ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

The data from 12 randomized controlled trials (over 4 thousand of children with known anthropometric data), investigating efficacy of supplement of vitamins and minerals in complex drug to the increase of height and weight in children were included. Proved that routine prescription of micronutrients...

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Main Author: R.T. Saygitov
Format: Article
Language:English
Published: "Paediatrician" Publishers LLC 2008-06-01
Series:Вопросы современной педиатрии
Online Access:https://vsp.spr-journal.ru/jour/article/view/1399
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author R.T. Saygitov
author_facet R.T. Saygitov
author_sort R.T. Saygitov
collection DOAJ
description The data from 12 randomized controlled trials (over 4 thousand of children with known anthropometric data), investigating efficacy of supplement of vitamins and minerals in complex drug to the increase of height and weight in children were included. Proved that routine prescription of micronutrients is accompanied by increase of children's height — standardized mean difference (smd) was 0,28 (95% ci — 0,09; 0,47) (р = 0,003). Maximal efficacy of micronutrients supply was registered in subgroup of stunted children with heightbage zbscores (haz) < b2,0 — SMD 0,58 (0,33; 0,84) (p < 0,001) and in children over 5 years — SMD 0,42 (0,07; 0,78) (р = 0,02). micronutrients don't affect body weight, HAZ, WAZ (weightbage zbscores) and WHZ (weight height zbscores). The results of trials were heterogeneous. The reasons of heterogeneity were a difference in age of children, growth and body weight dynamics, and duration of trial. This metabanalysis indicates that routine micronutrients supply doesn't affect children's body weight, but favors to increase of their growth compared to placebo. Micronutrients show maximal activity in stunted children.Key words: children, micronutrients, height, weight, meta analysis.
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spelling doaj.art-641319c29c124c058fc172c99d2aa4e72025-03-02T11:34:16Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352008-06-017358651399MICRONUTRIENTS AND CHILDREN'S PHYSICAL GROWTH: A META ANALYSIS OF RANDOMIZED CONTROLLED TRIALSR.T. Saygitov0Scientific Center of Children's Health, Russian Academy of Medical Sciences, MoscowThe data from 12 randomized controlled trials (over 4 thousand of children with known anthropometric data), investigating efficacy of supplement of vitamins and minerals in complex drug to the increase of height and weight in children were included. Proved that routine prescription of micronutrients is accompanied by increase of children's height — standardized mean difference (smd) was 0,28 (95% ci — 0,09; 0,47) (р = 0,003). Maximal efficacy of micronutrients supply was registered in subgroup of stunted children with heightbage zbscores (haz) < b2,0 — SMD 0,58 (0,33; 0,84) (p < 0,001) and in children over 5 years — SMD 0,42 (0,07; 0,78) (р = 0,02). micronutrients don't affect body weight, HAZ, WAZ (weightbage zbscores) and WHZ (weight height zbscores). The results of trials were heterogeneous. The reasons of heterogeneity were a difference in age of children, growth and body weight dynamics, and duration of trial. This metabanalysis indicates that routine micronutrients supply doesn't affect children's body weight, but favors to increase of their growth compared to placebo. Micronutrients show maximal activity in stunted children.Key words: children, micronutrients, height, weight, meta analysis.https://vsp.spr-journal.ru/jour/article/view/1399
spellingShingle R.T. Saygitov
MICRONUTRIENTS AND CHILDREN'S PHYSICAL GROWTH: A META ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Вопросы современной педиатрии
title MICRONUTRIENTS AND CHILDREN'S PHYSICAL GROWTH: A META ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
title_full MICRONUTRIENTS AND CHILDREN'S PHYSICAL GROWTH: A META ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
title_fullStr MICRONUTRIENTS AND CHILDREN'S PHYSICAL GROWTH: A META ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
title_full_unstemmed MICRONUTRIENTS AND CHILDREN'S PHYSICAL GROWTH: A META ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
title_short MICRONUTRIENTS AND CHILDREN'S PHYSICAL GROWTH: A META ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
title_sort micronutrients and children s physical growth a meta analysis of randomized controlled trials
url https://vsp.spr-journal.ru/jour/article/view/1399
work_keys_str_mv AT rtsaygitov micronutrientsandchildrensphysicalgrowthametaanalysisofrandomizedcontrolledtrials