Interleukin-12 Peripheral Blood Levels in Asthmatic Children
<p/> <p>Interleukin-12 (IL-12) was measured in 45 asthmatic children aged 3 to 16 years. The assessments were performed on 20 children during an episode of acute exacerbation and on 25 children during remission. There was no significant difference between the mean IL-12 level during exac...
Main Authors: | , , |
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Format: | Article |
Language: | English |
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BMC
2007-12-01
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Series: | Allergy, Asthma & Clinical Immunology |
Subjects: | |
Online Access: | http://www.aacijournal.com/content/3/4/128 |
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author | Soferman Ruth Rosenzwig Idit Fireman Elizabeth |
author_facet | Soferman Ruth Rosenzwig Idit Fireman Elizabeth |
author_sort | Soferman Ruth |
collection | DOAJ |
description | <p/> <p>Interleukin-12 (IL-12) was measured in 45 asthmatic children aged 3 to 16 years. The assessments were performed on 20 children during an episode of acute exacerbation and on 25 children during remission. There was no significant difference between the mean IL-12 level during exacerbation (1.63 ± 2.08 pg/mL) and during remission (0.88 ± 0.56 pg/mL) (<it>p </it>= .83). A positive, but insignificant, correlation was found between forced expiratory volume in 1 second and IL-12 (<it>p </it>= .634). IL-12 levels were significantly lower in children with a positive family history of asthma (1.13 ± 1.78 pg/mL) compared with those without (1.31 ± 1.06 pg/mL) (<it>p </it>< .012), supporting the theory that the gene-environment interactions affect the immune responses. IL-12 peripheral blood levels had no detectable impact on the course of established asthma in the study population.</p> |
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format | Article |
id | doaj.art-6414331672bd447298408aaf22064bc4 |
institution | Directory Open Access Journal |
issn | 1710-1484 1710-1492 |
language | English |
last_indexed | 2024-04-13T02:40:22Z |
publishDate | 2007-12-01 |
publisher | BMC |
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series | Allergy, Asthma & Clinical Immunology |
spelling | doaj.art-6414331672bd447298408aaf22064bc42022-12-22T03:06:14ZengBMCAllergy, Asthma & Clinical Immunology1710-14841710-14922007-12-013412813310.1186/1710-1492-3-4-128Interleukin-12 Peripheral Blood Levels in Asthmatic ChildrenSoferman RuthRosenzwig IditFireman Elizabeth<p/> <p>Interleukin-12 (IL-12) was measured in 45 asthmatic children aged 3 to 16 years. The assessments were performed on 20 children during an episode of acute exacerbation and on 25 children during remission. There was no significant difference between the mean IL-12 level during exacerbation (1.63 ± 2.08 pg/mL) and during remission (0.88 ± 0.56 pg/mL) (<it>p </it>= .83). A positive, but insignificant, correlation was found between forced expiratory volume in 1 second and IL-12 (<it>p </it>= .634). IL-12 levels were significantly lower in children with a positive family history of asthma (1.13 ± 1.78 pg/mL) compared with those without (1.31 ± 1.06 pg/mL) (<it>p </it>< .012), supporting the theory that the gene-environment interactions affect the immune responses. IL-12 peripheral blood levels had no detectable impact on the course of established asthma in the study population.</p>http://www.aacijournal.com/content/3/4/128asthmafamily historyIL-12 |
spellingShingle | Soferman Ruth Rosenzwig Idit Fireman Elizabeth Interleukin-12 Peripheral Blood Levels in Asthmatic Children Allergy, Asthma & Clinical Immunology asthma family history IL-12 |
title | Interleukin-12 Peripheral Blood Levels in Asthmatic Children |
title_full | Interleukin-12 Peripheral Blood Levels in Asthmatic Children |
title_fullStr | Interleukin-12 Peripheral Blood Levels in Asthmatic Children |
title_full_unstemmed | Interleukin-12 Peripheral Blood Levels in Asthmatic Children |
title_short | Interleukin-12 Peripheral Blood Levels in Asthmatic Children |
title_sort | interleukin 12 peripheral blood levels in asthmatic children |
topic | asthma family history IL-12 |
url | http://www.aacijournal.com/content/3/4/128 |
work_keys_str_mv | AT sofermanruth interleukin12peripheralbloodlevelsinasthmaticchildren AT rosenzwigidit interleukin12peripheralbloodlevelsinasthmaticchildren AT firemanelizabeth interleukin12peripheralbloodlevelsinasthmaticchildren |