Interleukin-12 Peripheral Blood Levels in Asthmatic Children
<p/> <p>Interleukin-12 (IL-12) was measured in 45 asthmatic children aged 3 to 16 years. The assessments were performed on 20 children during an episode of acute exacerbation and on 25 children during remission. There was no significant difference between the mean IL-12 level during exac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-12-01
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| Series: | Allergy, Asthma & Clinical Immunology |
| Subjects: | |
| Online Access: | http://www.aacijournal.com/content/3/4/128 |
| _version_ | 1811285168963452928 |
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| author | Soferman Ruth Rosenzwig Idit Fireman Elizabeth |
| author_facet | Soferman Ruth Rosenzwig Idit Fireman Elizabeth |
| author_sort | Soferman Ruth |
| collection | DOAJ |
| description | <p/> <p>Interleukin-12 (IL-12) was measured in 45 asthmatic children aged 3 to 16 years. The assessments were performed on 20 children during an episode of acute exacerbation and on 25 children during remission. There was no significant difference between the mean IL-12 level during exacerbation (1.63 ± 2.08 pg/mL) and during remission (0.88 ± 0.56 pg/mL) (<it>p </it>= .83). A positive, but insignificant, correlation was found between forced expiratory volume in 1 second and IL-12 (<it>p </it>= .634). IL-12 levels were significantly lower in children with a positive family history of asthma (1.13 ± 1.78 pg/mL) compared with those without (1.31 ± 1.06 pg/mL) (<it>p </it>< .012), supporting the theory that the gene-environment interactions affect the immune responses. IL-12 peripheral blood levels had no detectable impact on the course of established asthma in the study population.</p> |
| first_indexed | 2024-04-13T02:40:22Z |
| format | Article |
| id | doaj.art-6414331672bd447298408aaf22064bc4 |
| institution | Directory Open Access Journal |
| issn | 1710-1484 1710-1492 |
| language | English |
| last_indexed | 2024-04-13T02:40:22Z |
| publishDate | 2007-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-6414331672bd447298408aaf22064bc42022-12-22T03:06:14ZengBMCAllergy, Asthma & Clinical Immunology1710-14841710-14922007-12-013412813310.1186/1710-1492-3-4-128Interleukin-12 Peripheral Blood Levels in Asthmatic ChildrenSoferman RuthRosenzwig IditFireman Elizabeth<p/> <p>Interleukin-12 (IL-12) was measured in 45 asthmatic children aged 3 to 16 years. The assessments were performed on 20 children during an episode of acute exacerbation and on 25 children during remission. There was no significant difference between the mean IL-12 level during exacerbation (1.63 ± 2.08 pg/mL) and during remission (0.88 ± 0.56 pg/mL) (<it>p </it>= .83). A positive, but insignificant, correlation was found between forced expiratory volume in 1 second and IL-12 (<it>p </it>= .634). IL-12 levels were significantly lower in children with a positive family history of asthma (1.13 ± 1.78 pg/mL) compared with those without (1.31 ± 1.06 pg/mL) (<it>p </it>< .012), supporting the theory that the gene-environment interactions affect the immune responses. IL-12 peripheral blood levels had no detectable impact on the course of established asthma in the study population.</p>http://www.aacijournal.com/content/3/4/128asthmafamily historyIL-12 |
| spellingShingle | Soferman Ruth Rosenzwig Idit Fireman Elizabeth Interleukin-12 Peripheral Blood Levels in Asthmatic Children Allergy, Asthma & Clinical Immunology asthma family history IL-12 |
| title | Interleukin-12 Peripheral Blood Levels in Asthmatic Children |
| title_full | Interleukin-12 Peripheral Blood Levels in Asthmatic Children |
| title_fullStr | Interleukin-12 Peripheral Blood Levels in Asthmatic Children |
| title_full_unstemmed | Interleukin-12 Peripheral Blood Levels in Asthmatic Children |
| title_short | Interleukin-12 Peripheral Blood Levels in Asthmatic Children |
| title_sort | interleukin 12 peripheral blood levels in asthmatic children |
| topic | asthma family history IL-12 |
| url | http://www.aacijournal.com/content/3/4/128 |
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