TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATION
This review summarizes the current literature devoted to the analysis of the role of transforming growth factor beta 1 (TGF-β1) at liver transplantation. TGF-β1 plays a key role in the development of liver fi brosis, as well as in development of the immune response; its concentration in the blood an...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2015-10-01
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| Series: | Вестник трансплантологии и искусственных органов |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/569 |
| _version_ | 1826546419421413376 |
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| author | R. M. Kurabekova O. P. Shevchenko O. M. Tsiroulnikova |
| author_facet | R. M. Kurabekova O. P. Shevchenko O. M. Tsiroulnikova |
| author_sort | R. M. Kurabekova |
| collection | DOAJ |
| description | This review summarizes the current literature devoted to the analysis of the role of transforming growth factor beta 1 (TGF-β1) at liver transplantation. TGF-β1 plays a key role in the development of liver fi brosis, as well as in development of the immune response; its concentration in the blood and tissue changes in liver diseases. TGF-β1 levels in the blood of the recipients are associated with the development of liver fi brosis, the formation of immune tolerance and immune response to active infection. Measuring the level of TGF-β1 at liver transplantation may have diagnostic and prognostic value for assessing the graft condition. Currently, clinical data on the role of the cytokine at liver transplantation are not accumulated enough and further research on the relation of TGF-β1 levels with different clinical and laboratory parameters in liver transplant patients is needed. The review analyzed 54 sources of literature, more than half of which were published in the last fi ve years. |
| first_indexed | 2024-04-10T00:52:57Z |
| format | Article |
| id | doaj.art-641581bf1acf4dd8a7fa24939d93fcad |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2025-03-14T05:33:27Z |
| publishDate | 2015-10-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj.art-641581bf1acf4dd8a7fa24939d93fcad2025-03-05T14:11:48ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912015-10-01173768210.15825/1995-1191-2015-3-76-82492TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATIONR. M. Kurabekova0O. P. Shevchenko1O. M. Tsiroulnikova2V.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation, Moscow, Russian FederationV.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Department of transplantology and artifi cial organs, Moscow, Russian FederationV.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Department of transplantology and artifi cial organs, Moscow, Russian FederationThis review summarizes the current literature devoted to the analysis of the role of transforming growth factor beta 1 (TGF-β1) at liver transplantation. TGF-β1 plays a key role in the development of liver fi brosis, as well as in development of the immune response; its concentration in the blood and tissue changes in liver diseases. TGF-β1 levels in the blood of the recipients are associated with the development of liver fi brosis, the formation of immune tolerance and immune response to active infection. Measuring the level of TGF-β1 at liver transplantation may have diagnostic and prognostic value for assessing the graft condition. Currently, clinical data on the role of the cytokine at liver transplantation are not accumulated enough and further research on the relation of TGF-β1 levels with different clinical and laboratory parameters in liver transplant patients is needed. The review analyzed 54 sources of literature, more than half of which were published in the last fi ve years.https://journal.transpl.ru/vtio/article/view/569liver transplantationtgf-β1biomarkerscytokines |
| spellingShingle | R. M. Kurabekova O. P. Shevchenko O. M. Tsiroulnikova TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATION Вестник трансплантологии и искусственных органов liver transplantation tgf-β1 biomarkers cytokines |
| title | TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATION |
| title_full | TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATION |
| title_fullStr | TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATION |
| title_full_unstemmed | TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATION |
| title_short | TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATION |
| title_sort | transforming growth factor 1 at liver transplantation |
| topic | liver transplantation tgf-β1 biomarkers cytokines |
| url | https://journal.transpl.ru/vtio/article/view/569 |
| work_keys_str_mv | AT rmkurabekova transforminggrowthfactor1atlivertransplantation AT opshevchenko transforminggrowthfactor1atlivertransplantation AT omtsiroulnikova transforminggrowthfactor1atlivertransplantation |