Association of Folic Acid Supplementation in Early Pregnancy with Risk of Gestational Diabetes Mellitus: A Longitudinal Study
Background: Gestational diabetes mellitus (GDM) may lead to many adverse effects on women and their offspring. Method: 24,429 pregnant women were enrolled during early pregnancy from January 2018 to December 2021. The self-reported intake of folic acid supplements was assessed via a questionnaire. O...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/19/4061 |
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| author | Hongyan Chen Yaqiong Hu Yannan Li Wenzheng Zhou Niya Zhou Huan Yang Qing Chen Yawen Li Qiao Huang Zhen Chen |
| author_facet | Hongyan Chen Yaqiong Hu Yannan Li Wenzheng Zhou Niya Zhou Huan Yang Qing Chen Yawen Li Qiao Huang Zhen Chen |
| author_sort | Hongyan Chen |
| collection | DOAJ |
| description | Background: Gestational diabetes mellitus (GDM) may lead to many adverse effects on women and their offspring. Method: 24,429 pregnant women were enrolled during early pregnancy from January 2018 to December 2021. The self-reported intake of folic acid supplements was assessed via a questionnaire. Oral glucose tolerance tests were used for the diagnosis of GDM. The association between intake or not, dose, and duration of folic acid and GDM risk was assessed. Results: 6396 (26.18%) women were diagnosed with GDM. In the univariate models, folic acid was found to be correlated with total GDM risk (OR = 0.82, 95% CI: 0.70~0.95, <i>p</i> = 0.009). After adjusting for potential confounders, the association with total GDM risk was not significant, but the association of folic acid with 2-h PBG diagnosed GDM risk was consistently significant (OR = 0.75, 95% CI: 0.63~0.90, <i>p</i> = 0.002). No significant association between the dose and duration of folic acid supplementation and GDM risk was observed in the analyses. Conclusion: Folic acid supplementation might be a protective factor for the risk of GDM caused by the high level of postprandial blood glucose, but the dose or duration-related association between folic acid supplementation and GDM risk is not clear. |
| first_indexed | 2024-03-09T21:19:45Z |
| format | Article |
| id | doaj.art-6417c4e6126a496b98a9743a026f2fcc |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T21:19:45Z |
| publishDate | 2022-09-01 |
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| series | Nutrients |
| spelling | doaj.art-6417c4e6126a496b98a9743a026f2fcc2023-11-23T21:24:58ZengMDPI AGNutrients2072-66432022-09-011419406110.3390/nu14194061Association of Folic Acid Supplementation in Early Pregnancy with Risk of Gestational Diabetes Mellitus: A Longitudinal StudyHongyan Chen0Yaqiong Hu1Yannan Li2Wenzheng Zhou3Niya Zhou4Huan Yang5Qing Chen6Yawen Li7Qiao Huang8Zhen Chen9Department of Quality Management, Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, ChinaDepartment of Quality Management, Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, ChinaDepartment of Quality Management, Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, ChinaDepartment of Quality Management, Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, ChinaClinical Research Center, Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, ChinaKey Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Army Medical University, Chongqing 400038, ChinaKey Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Army Medical University, Chongqing 400038, ChinaKey Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Army Medical University, Chongqing 400038, ChinaDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, ChinaDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, ChinaBackground: Gestational diabetes mellitus (GDM) may lead to many adverse effects on women and their offspring. Method: 24,429 pregnant women were enrolled during early pregnancy from January 2018 to December 2021. The self-reported intake of folic acid supplements was assessed via a questionnaire. Oral glucose tolerance tests were used for the diagnosis of GDM. The association between intake or not, dose, and duration of folic acid and GDM risk was assessed. Results: 6396 (26.18%) women were diagnosed with GDM. In the univariate models, folic acid was found to be correlated with total GDM risk (OR = 0.82, 95% CI: 0.70~0.95, <i>p</i> = 0.009). After adjusting for potential confounders, the association with total GDM risk was not significant, but the association of folic acid with 2-h PBG diagnosed GDM risk was consistently significant (OR = 0.75, 95% CI: 0.63~0.90, <i>p</i> = 0.002). No significant association between the dose and duration of folic acid supplementation and GDM risk was observed in the analyses. Conclusion: Folic acid supplementation might be a protective factor for the risk of GDM caused by the high level of postprandial blood glucose, but the dose or duration-related association between folic acid supplementation and GDM risk is not clear.https://www.mdpi.com/2072-6643/14/19/4061folic acidgestational diabetes mellitusdosedurationrisk |
| spellingShingle | Hongyan Chen Yaqiong Hu Yannan Li Wenzheng Zhou Niya Zhou Huan Yang Qing Chen Yawen Li Qiao Huang Zhen Chen Association of Folic Acid Supplementation in Early Pregnancy with Risk of Gestational Diabetes Mellitus: A Longitudinal Study Nutrients folic acid gestational diabetes mellitus dose duration risk |
| title | Association of Folic Acid Supplementation in Early Pregnancy with Risk of Gestational Diabetes Mellitus: A Longitudinal Study |
| title_full | Association of Folic Acid Supplementation in Early Pregnancy with Risk of Gestational Diabetes Mellitus: A Longitudinal Study |
| title_fullStr | Association of Folic Acid Supplementation in Early Pregnancy with Risk of Gestational Diabetes Mellitus: A Longitudinal Study |
| title_full_unstemmed | Association of Folic Acid Supplementation in Early Pregnancy with Risk of Gestational Diabetes Mellitus: A Longitudinal Study |
| title_short | Association of Folic Acid Supplementation in Early Pregnancy with Risk of Gestational Diabetes Mellitus: A Longitudinal Study |
| title_sort | association of folic acid supplementation in early pregnancy with risk of gestational diabetes mellitus a longitudinal study |
| topic | folic acid gestational diabetes mellitus dose duration risk |
| url | https://www.mdpi.com/2072-6643/14/19/4061 |
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