A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury
Mild traumatic brain injury (TBI) results in chronic affective disorders such as depression, anxiety, and fear that persist up to years following injury and significantly impair the quality of life for patients. Although a great deal of research has contributed to defining symptoms of mild TBI, ther...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.601275/full |
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| author | Taylor A. McCorkle Jessica R. Barson Jessica R. Barson Ramesh Raghupathi Ramesh Raghupathi |
| author_facet | Taylor A. McCorkle Jessica R. Barson Jessica R. Barson Ramesh Raghupathi Ramesh Raghupathi |
| author_sort | Taylor A. McCorkle |
| collection | DOAJ |
| description | Mild traumatic brain injury (TBI) results in chronic affective disorders such as depression, anxiety, and fear that persist up to years following injury and significantly impair the quality of life for patients. Although a great deal of research has contributed to defining symptoms of mild TBI, there are no adequate drug therapies for brain-injured individuals. Preclinical studies have modeled these deficits in affective behaviors post-injury to understand the underlying mechanisms with a view to developing appropriate treatment strategies. These studies have also unveiled sex differences that contribute to the varying phenotypes associated with each behavior. Although clinical and preclinical studies have viewed these behavioral deficits as separate entities with unique neurobiological mechanisms, mechanistic similarities suggest that a novel approach is needed to advance research on drug therapy. This review will discuss the circuitry involved in the expression of deficits in affective behaviors following mild TBI in humans and animals and provide evidence that the manifestation of impairment in these behaviors stems from an amygdala-dependent emotional processing deficit. It will highlight mechanistic similarities between these different types of affective behaviors that can potentially advance mild TBI drug therapy by investigating treatments for the deficits in affective behaviors as one entity, requiring the same treatment. |
| first_indexed | 2024-12-14T11:16:29Z |
| format | Article |
| id | doaj.art-6417e94bd6474f028b181f381ae5090e |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-14T11:16:29Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-6417e94bd6474f028b181f381ae5090e2022-12-21T23:04:00ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532021-03-011510.3389/fnbeh.2021.601275601275A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain InjuryTaylor A. McCorkle0Jessica R. Barson1Jessica R. Barson2Ramesh Raghupathi3Ramesh Raghupathi4Graduate Program in Neuroscience, Graduate School of Biomedical Sciences and Professional Studies, Drexel University College of Medicine, Philadelphia, PA, United StatesGraduate Program in Neuroscience, Graduate School of Biomedical Sciences and Professional Studies, Drexel University College of Medicine, Philadelphia, PA, United StatesDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, United StatesGraduate Program in Neuroscience, Graduate School of Biomedical Sciences and Professional Studies, Drexel University College of Medicine, Philadelphia, PA, United StatesDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, United StatesMild traumatic brain injury (TBI) results in chronic affective disorders such as depression, anxiety, and fear that persist up to years following injury and significantly impair the quality of life for patients. Although a great deal of research has contributed to defining symptoms of mild TBI, there are no adequate drug therapies for brain-injured individuals. Preclinical studies have modeled these deficits in affective behaviors post-injury to understand the underlying mechanisms with a view to developing appropriate treatment strategies. These studies have also unveiled sex differences that contribute to the varying phenotypes associated with each behavior. Although clinical and preclinical studies have viewed these behavioral deficits as separate entities with unique neurobiological mechanisms, mechanistic similarities suggest that a novel approach is needed to advance research on drug therapy. This review will discuss the circuitry involved in the expression of deficits in affective behaviors following mild TBI in humans and animals and provide evidence that the manifestation of impairment in these behaviors stems from an amygdala-dependent emotional processing deficit. It will highlight mechanistic similarities between these different types of affective behaviors that can potentially advance mild TBI drug therapy by investigating treatments for the deficits in affective behaviors as one entity, requiring the same treatment.https://www.frontiersin.org/articles/10.3389/fnbeh.2021.601275/fullmild TBIdepressionanxietyposttraumatic stress disorderbasolateral amygdalacentral amygdala |
| spellingShingle | Taylor A. McCorkle Jessica R. Barson Jessica R. Barson Ramesh Raghupathi Ramesh Raghupathi A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury Frontiers in Behavioral Neuroscience mild TBI depression anxiety posttraumatic stress disorder basolateral amygdala central amygdala |
| title | A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury |
| title_full | A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury |
| title_fullStr | A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury |
| title_full_unstemmed | A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury |
| title_short | A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury |
| title_sort | role for the amygdala in impairments of affective behaviors following mild traumatic brain injury |
| topic | mild TBI depression anxiety posttraumatic stress disorder basolateral amygdala central amygdala |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.601275/full |
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