Adaptation to human populations is revealed by within-host polymorphisms in HIV-1 and hepatitis C virus.

Adaptation to human populations is revealed by within-host polymorphisms in HIV-1 and hepatitis C virus.

CD8(+) cytotoxic T-lymphocytes (CTLs) perform a critical role in the immune control of viral infections, including those caused by human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). As a result, genetic variation at CTL epitopes is strongly influenced by host-specific selection...

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Bibliographic Details
Main Authors: Art F Y Poon, Sergei L Kosakovsky Pond, Phil Bennett, Douglas D Richman, Andrew J Leigh Brown, Simon D W Frost
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.0030045

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