Prevalence of elevated hepatic transaminases<b> </b>among Jordanian patients with type 2 diabetes mellitus
<b>Background and Objectives</b> : Since the extent of elevation of liver transaminases in type 2 diabetics in Jordan and most of the Middle East is unknown, we estimated the prevalence of elevated liver transaminase levels among patients with type 2 diabetes and determined associated ri...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2010-01-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2010;volume=30;issue=1;spage=25;epage=32;aulast=Judi |
| _version_ | 1818980502689808384 |
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| author | Judi Layla Toukan Ala Khader Yousef Ajlouni Kamel Khatib M |
| author_facet | Judi Layla Toukan Ala Khader Yousef Ajlouni Kamel Khatib M |
| author_sort | Judi Layla |
| collection | DOAJ |
| description | <b>Background and Objectives</b> : Since the extent of elevation of liver transaminases in type 2 diabetics in Jordan and most of the Middle East is unknown, we estimated the prevalence of elevated liver transaminase levels among patients with type 2 diabetes and determined associated risk factors. <b> Methods</b> : This study was performed on 1014 consecutive type 2 diabetic outpatients who attended the National Center for Diabetes, Endocrinology and Genetics in Amman, Jordan. The patients′ age ranged between 26-85 years with a mean age of 56.8 (+9.8). Three- hundred and fifty three (54.5%) were males with a median age of 58 years (ranging between 26-82 years), and four hundred and sixty one (45.5%) were females with a median age of 57 years (ranging between 28-85 years). Body mass index, waist circumference, lipid profile, and hepatic transaminase levels were recorded. Ultraonography was performed in those with elevated alanine transaminase levels. <b> Results</b> : Overall, the prevalence of elevated alanine transaminase (ALT) level was 10.4% (n=105) with the gender-wise prevalence being 12.8% (n=71) in men and 7.4% (n=34) in women. The prevalence of elevated aspartate transaminase (AST) levels was 5.4% (n=56) with the gender-wise prevalence being 5.6% (n=31) in men and 5.4% (n=25) in women.. Only 4.5% (n=44) showed elevated levels of both ALT and AST. Male gender (OR=2.35, CI:1.5-3.8) and high waist circumference (OR=1.9, CI:1.2-3.2) were associated with increased risk of elevated ALT levels. Younger patients had a higher tendency to have elevated ALT compared to those over 65 years (OR=12.4 for patients aged 25-45years, and OR=5.8 for those who were 45-65 years old). Non-insulin use was associated with a high odds ratio for elevated ALT levels (OR=1.7, CI: 1.1-2.9). <b>Conclusions</b> : Elevated ALT and AST levels are found in 10.4% and 5.4% of our type 2 diabetic patients respectively. Male gender, younger age, higher waist circumference; as an indicator of central obesity, as well as non insulin use are independent predictors of elevated liver transaminase levels. |
| first_indexed | 2024-12-20T17:16:27Z |
| format | Article |
| id | doaj.art-6419651658c54d20b3bd2a2eaecf97df |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-12-20T17:16:27Z |
| publishDate | 2010-01-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-6419651658c54d20b3bd2a2eaecf97df2022-12-21T19:32:00ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662010-01-013012532Prevalence of elevated hepatic transaminases<b> </b>among Jordanian patients with type 2 diabetes mellitusJudi LaylaToukan AlaKhader YousefAjlouni KamelKhatib M<b>Background and Objectives</b> : Since the extent of elevation of liver transaminases in type 2 diabetics in Jordan and most of the Middle East is unknown, we estimated the prevalence of elevated liver transaminase levels among patients with type 2 diabetes and determined associated risk factors. <b> Methods</b> : This study was performed on 1014 consecutive type 2 diabetic outpatients who attended the National Center for Diabetes, Endocrinology and Genetics in Amman, Jordan. The patients′ age ranged between 26-85 years with a mean age of 56.8 (+9.8). Three- hundred and fifty three (54.5%) were males with a median age of 58 years (ranging between 26-82 years), and four hundred and sixty one (45.5%) were females with a median age of 57 years (ranging between 28-85 years). Body mass index, waist circumference, lipid profile, and hepatic transaminase levels were recorded. Ultraonography was performed in those with elevated alanine transaminase levels. <b> Results</b> : Overall, the prevalence of elevated alanine transaminase (ALT) level was 10.4% (n=105) with the gender-wise prevalence being 12.8% (n=71) in men and 7.4% (n=34) in women. The prevalence of elevated aspartate transaminase (AST) levels was 5.4% (n=56) with the gender-wise prevalence being 5.6% (n=31) in men and 5.4% (n=25) in women.. Only 4.5% (n=44) showed elevated levels of both ALT and AST. Male gender (OR=2.35, CI:1.5-3.8) and high waist circumference (OR=1.9, CI:1.2-3.2) were associated with increased risk of elevated ALT levels. Younger patients had a higher tendency to have elevated ALT compared to those over 65 years (OR=12.4 for patients aged 25-45years, and OR=5.8 for those who were 45-65 years old). Non-insulin use was associated with a high odds ratio for elevated ALT levels (OR=1.7, CI: 1.1-2.9). <b>Conclusions</b> : Elevated ALT and AST levels are found in 10.4% and 5.4% of our type 2 diabetic patients respectively. Male gender, younger age, higher waist circumference; as an indicator of central obesity, as well as non insulin use are independent predictors of elevated liver transaminase levels.http://www.saudiannals.net/article.asp?issn=0256-4947;year=2010;volume=30;issue=1;spage=25;epage=32;aulast=Judi |
| spellingShingle | Judi Layla Toukan Ala Khader Yousef Ajlouni Kamel Khatib M Prevalence of elevated hepatic transaminases<b> </b>among Jordanian patients with type 2 diabetes mellitus Annals of Saudi Medicine |
| title | Prevalence of elevated hepatic transaminases<b> </b>among Jordanian patients with type 2 diabetes mellitus |
| title_full | Prevalence of elevated hepatic transaminases<b> </b>among Jordanian patients with type 2 diabetes mellitus |
| title_fullStr | Prevalence of elevated hepatic transaminases<b> </b>among Jordanian patients with type 2 diabetes mellitus |
| title_full_unstemmed | Prevalence of elevated hepatic transaminases<b> </b>among Jordanian patients with type 2 diabetes mellitus |
| title_short | Prevalence of elevated hepatic transaminases<b> </b>among Jordanian patients with type 2 diabetes mellitus |
| title_sort | prevalence of elevated hepatic transaminases b b among jordanian patients with type 2 diabetes mellitus |
| url | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2010;volume=30;issue=1;spage=25;epage=32;aulast=Judi |
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