Suppression of Poxvirus Replication by Resveratrol
Poxviruses continue to cause serious diseases even after eradication of the historically deadly infectious human disease, smallpox. Poxviruses are currently being developed as vaccine vectors and cancer therapeutic agents. Resveratrol is a natural polyphenol stilbenoid found in plants that has been...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2017.02196/full |
| _version_ | 1818509477131845632 |
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| author | Shuai Cao Susan Realegeno Anil Pant Panayampalli S. Satheshkumar Zhilong Yang |
| author_facet | Shuai Cao Susan Realegeno Anil Pant Panayampalli S. Satheshkumar Zhilong Yang |
| author_sort | Shuai Cao |
| collection | DOAJ |
| description | Poxviruses continue to cause serious diseases even after eradication of the historically deadly infectious human disease, smallpox. Poxviruses are currently being developed as vaccine vectors and cancer therapeutic agents. Resveratrol is a natural polyphenol stilbenoid found in plants that has been shown to inhibit or enhance replication of a number of viruses, but the effect of resveratrol on poxvirus replication is unknown. In the present study, we found that resveratrol dramatically suppressed the replication of vaccinia virus (VACV), the prototypic member of poxviruses, in various cell types. Resveratrol also significantly reduced the replication of monkeypox virus, a zoonotic virus that is endemic in Western and Central Africa and causes human mortality. The inhibitory effect of resveratrol on poxviruses is independent of VACV N1 protein, a potential resveratrol binding target. Further experiments demonstrated that resveratrol had little effect on VACV early gene expression, while it suppressed VACV DNA synthesis, and subsequently post-replicative gene expression. |
| first_indexed | 2024-12-10T22:45:58Z |
| format | Article |
| id | doaj.art-641a586925734940a86480df7962b6ad |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-10T22:45:58Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-641a586925734940a86480df7962b6ad2022-12-22T01:30:34ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-11-01810.3389/fmicb.2017.02196307678Suppression of Poxvirus Replication by ResveratrolShuai Cao0Susan Realegeno1Anil Pant2Panayampalli S. Satheshkumar3Zhilong Yang4Division of Biology, Kansas State University, Manhattan, KS, United StatesPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United StatesDivision of Biology, Kansas State University, Manhattan, KS, United StatesPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United StatesDivision of Biology, Kansas State University, Manhattan, KS, United StatesPoxviruses continue to cause serious diseases even after eradication of the historically deadly infectious human disease, smallpox. Poxviruses are currently being developed as vaccine vectors and cancer therapeutic agents. Resveratrol is a natural polyphenol stilbenoid found in plants that has been shown to inhibit or enhance replication of a number of viruses, but the effect of resveratrol on poxvirus replication is unknown. In the present study, we found that resveratrol dramatically suppressed the replication of vaccinia virus (VACV), the prototypic member of poxviruses, in various cell types. Resveratrol also significantly reduced the replication of monkeypox virus, a zoonotic virus that is endemic in Western and Central Africa and causes human mortality. The inhibitory effect of resveratrol on poxviruses is independent of VACV N1 protein, a potential resveratrol binding target. Further experiments demonstrated that resveratrol had little effect on VACV early gene expression, while it suppressed VACV DNA synthesis, and subsequently post-replicative gene expression.http://journal.frontiersin.org/article/10.3389/fmicb.2017.02196/fullpoxvirusvaccinia virusmonkeypoxresveratrolDNA synthesisgene expression |
| spellingShingle | Shuai Cao Susan Realegeno Anil Pant Panayampalli S. Satheshkumar Zhilong Yang Suppression of Poxvirus Replication by Resveratrol Frontiers in Microbiology poxvirus vaccinia virus monkeypox resveratrol DNA synthesis gene expression |
| title | Suppression of Poxvirus Replication by Resveratrol |
| title_full | Suppression of Poxvirus Replication by Resveratrol |
| title_fullStr | Suppression of Poxvirus Replication by Resveratrol |
| title_full_unstemmed | Suppression of Poxvirus Replication by Resveratrol |
| title_short | Suppression of Poxvirus Replication by Resveratrol |
| title_sort | suppression of poxvirus replication by resveratrol |
| topic | poxvirus vaccinia virus monkeypox resveratrol DNA synthesis gene expression |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2017.02196/full |
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