microRNA-184 in the landscape of human malignancies: a review to roles and clinical significance
Abstract MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) with a short length of 19–22 nucleotides. miRNAs are posttranscriptional regulators of gene expression involved in various biological processes like cell growth, apoptosis, and angiogenesis. miR-184 is a well-studied miRNA, for whic...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-11-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01718-1 |
| _version_ | 1797453881442041856 |
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| author | Mehdi Fattahi Delsuz Rezaee Fatemeh Fakhari Sajad Najafi Seyed Mohsen Aghaei-Zarch Parisa Beyranvand Mohammad Amin Rashidi Saeid Bagheri-Mohammadi Fahimeh Zamani-Rarani Mohammad Bakhtiari Abbas Bakhtiari Shahab Falahi Azra Kenarkoohi Jamal Majidpoor P. U. Nguyen |
| author_facet | Mehdi Fattahi Delsuz Rezaee Fatemeh Fakhari Sajad Najafi Seyed Mohsen Aghaei-Zarch Parisa Beyranvand Mohammad Amin Rashidi Saeid Bagheri-Mohammadi Fahimeh Zamani-Rarani Mohammad Bakhtiari Abbas Bakhtiari Shahab Falahi Azra Kenarkoohi Jamal Majidpoor P. U. Nguyen |
| author_sort | Mehdi Fattahi |
| collection | DOAJ |
| description | Abstract MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) with a short length of 19–22 nucleotides. miRNAs are posttranscriptional regulators of gene expression involved in various biological processes like cell growth, apoptosis, and angiogenesis. miR-184 is a well-studied miRNA, for which most studies report its downregulation in cancer cells and tissues and experiments support its role as a tumor suppressor inhibiting malignant biological behaviors of cancer cells in vitro and in vivo. To exert its functions, miR-184 affects some signaling pathways involved in tumorigenesis like Wnt and β-catenin, and AKT/mTORC1 pathway, oncogenic factors (e.g., c-Myc) or apoptotic proteins, such as Bcl-2. Interestingly, clinical investigations have shown miR-184 with good performance as a prognostic/diagnostic biomarker for various cancers. Additionally, exogenous miR-184 in cell and xenograft animal studies suggest it as a therapeutic anticancer target. In this review, we outline the studies that evaluated the roles of miR-184 in tumorigenesis as well as its clinical significance. |
| first_indexed | 2024-03-09T15:29:16Z |
| format | Article |
| id | doaj.art-641aa56da6de4815a2abb76330415688 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-03-09T15:29:16Z |
| publishDate | 2023-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-641aa56da6de4815a2abb763304156882023-11-26T12:21:45ZengNature Publishing GroupCell Death Discovery2058-77162023-11-019111510.1038/s41420-023-01718-1microRNA-184 in the landscape of human malignancies: a review to roles and clinical significanceMehdi Fattahi0Delsuz Rezaee1Fatemeh Fakhari2Sajad Najafi3Seyed Mohsen Aghaei-Zarch4Parisa Beyranvand5Mohammad Amin Rashidi6Saeid Bagheri-Mohammadi7Fahimeh Zamani-Rarani8Mohammad Bakhtiari9Abbas Bakhtiari10Shahab Falahi11Azra Kenarkoohi12Jamal Majidpoor13P. U. Nguyen14Institute of Research and Development, Duy Tan UniversitySchool of Allied Medical Sciences, Ilam University of Medical SciencesDepartment of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical SciencesDepartment of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Molecular Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB)Student Research Committee, Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical SciencesDepartment of Physiology and Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Anatomical Sciences, School of Medicine, Isfahan University of Medical SciencesBehbahan Faculty of Medical SciencesAnatomical Sciences Department, Medical Faculty, Hamadan University of Medical SciencesZoonotic Diseases Research Center, Ilam University of Medical SciencesZoonotic Diseases Research Center, Ilam University of Medical SciencesDepartment of Anatomy, Faculty of Medicine, Infectious Disease Research Center, Gonabad University of Medical SciencesInstitute of Research and Development, Duy Tan UniversityAbstract MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) with a short length of 19–22 nucleotides. miRNAs are posttranscriptional regulators of gene expression involved in various biological processes like cell growth, apoptosis, and angiogenesis. miR-184 is a well-studied miRNA, for which most studies report its downregulation in cancer cells and tissues and experiments support its role as a tumor suppressor inhibiting malignant biological behaviors of cancer cells in vitro and in vivo. To exert its functions, miR-184 affects some signaling pathways involved in tumorigenesis like Wnt and β-catenin, and AKT/mTORC1 pathway, oncogenic factors (e.g., c-Myc) or apoptotic proteins, such as Bcl-2. Interestingly, clinical investigations have shown miR-184 with good performance as a prognostic/diagnostic biomarker for various cancers. Additionally, exogenous miR-184 in cell and xenograft animal studies suggest it as a therapeutic anticancer target. In this review, we outline the studies that evaluated the roles of miR-184 in tumorigenesis as well as its clinical significance.https://doi.org/10.1038/s41420-023-01718-1 |
| spellingShingle | Mehdi Fattahi Delsuz Rezaee Fatemeh Fakhari Sajad Najafi Seyed Mohsen Aghaei-Zarch Parisa Beyranvand Mohammad Amin Rashidi Saeid Bagheri-Mohammadi Fahimeh Zamani-Rarani Mohammad Bakhtiari Abbas Bakhtiari Shahab Falahi Azra Kenarkoohi Jamal Majidpoor P. U. Nguyen microRNA-184 in the landscape of human malignancies: a review to roles and clinical significance Cell Death Discovery |
| title | microRNA-184 in the landscape of human malignancies: a review to roles and clinical significance |
| title_full | microRNA-184 in the landscape of human malignancies: a review to roles and clinical significance |
| title_fullStr | microRNA-184 in the landscape of human malignancies: a review to roles and clinical significance |
| title_full_unstemmed | microRNA-184 in the landscape of human malignancies: a review to roles and clinical significance |
| title_short | microRNA-184 in the landscape of human malignancies: a review to roles and clinical significance |
| title_sort | microrna 184 in the landscape of human malignancies a review to roles and clinical significance |
| url | https://doi.org/10.1038/s41420-023-01718-1 |
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