X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development

X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development

Summary: HUWE1 is a HECT-domain ubiquitin E3 ligase expressed in various tissues. Although HUWE1 is known to promote degradation of the tumor suppressor p53, given a growing list of its substrates, in vivo functions of HUWE1 remain elusive. Here, we investigated the role of HUWE1 in the female repro...

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Bibliographic Details
Main Authors: Alaa A. Eisa, Scott Bang, Katherine J. Crawford, Emily M. Murphy, William W. Feng, Souvik Dey, Wendy Wells, Ning Kon, Wei Gu, Lisa M. Mehlmann, Srinivasan Vijayaraghavan, Manabu Kurokawa
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Cell Biology
Developmental Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030715X

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http://www.sciencedirect.com/science/article/pii/S258900422030715X

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