The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium
BackgroundBoth ketamine and priming may accelerate the onset time of neuromuscular blocking agents. We investigate the effect of low dose ketamine and cisatracurium priming on the intubating condition and onset time of cisatracurium.MethodsAfter Institutional Review Board approval, 120 consecutive p...
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2012-10-01
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| Series: | Korean Journal of Anesthesiology |
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| Online Access: | http://ekja.org/upload/pdf/kjae-63-308.pdf |
| _version_ | 1818417289438953472 |
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| author | Byung-Ryang Ahn Sang-Hun Kim Byung-Sik Yu Kyung-Joon Lim Jong-June Sun |
| author_facet | Byung-Ryang Ahn Sang-Hun Kim Byung-Sik Yu Kyung-Joon Lim Jong-June Sun |
| author_sort | Byung-Ryang Ahn |
| collection | DOAJ |
| description | BackgroundBoth ketamine and priming may accelerate the onset time of neuromuscular blocking agents. We investigate the effect of low dose ketamine and cisatracurium priming on the intubating condition and onset time of cisatracurium.MethodsAfter Institutional Review Board approval, 120 consecutive patients undergoing general anesthesia were randomly assigned to one of 4 groups. All patients were injected one of normal saline (group C), cisatracurium 0.01 mg/kg (group P), ketamine 0.5 mg/kg (group K) and combination of cisatracurium 0.01 mg/kg, and ketamine 0.5 mg/kg (group PK) diluted into a 5 ml solution, followed 3 minutes later by cisatracurium 0.15 mg/kg in group C and K, and 0.14 mg/kg cisatracurium in priming group. Onset time was recorded the electromyographical responses using single twitch and intubating conditions were evaluated at 60 seconds after cisatracurium administration.ResultsThe mean onset time was most significantly accelerated in Group PK and was also significantly more accelerated in Group P and K compared with Group C (P < 0.008). It was 112.7 ± 13.2, 91.4 ± 17.9, 84.9 ± 12.7 and 76.4 ± 8.3 seconds in Group C, P, K, and PK, respectively. Intubating conditions were significantly improved in Group P, K and PK than Group C (P < 0.008). Especially, Group PK showed most significant improvement of intubating conditions.ConclusionsThe combination of the low dose ketamine and cisatracurium priming accelerated the onset time and was improved the intubating conditions. |
| first_indexed | 2024-12-14T12:04:25Z |
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| id | doaj.art-641afefe11f74fc8bbb396df2d72d8fd |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-14T12:04:25Z |
| publishDate | 2012-10-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-641afefe11f74fc8bbb396df2d72d8fd2022-12-21T23:01:55ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632012-10-0163430831310.4097/kjae.2012.63.4.3087429The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracuriumByung-Ryang Ahn0Sang-Hun Kim1Byung-Sik Yu2Kyung-Joon Lim3Jong-June Sun4Department of Anesthesiology and Pain Medicine, Chosun University Hospital, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chosun University School of Medicine, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chosun University School of Medicine, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chosun University School of Medicine, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chosun University Hospital, Gwangju, Korea.BackgroundBoth ketamine and priming may accelerate the onset time of neuromuscular blocking agents. We investigate the effect of low dose ketamine and cisatracurium priming on the intubating condition and onset time of cisatracurium.MethodsAfter Institutional Review Board approval, 120 consecutive patients undergoing general anesthesia were randomly assigned to one of 4 groups. All patients were injected one of normal saline (group C), cisatracurium 0.01 mg/kg (group P), ketamine 0.5 mg/kg (group K) and combination of cisatracurium 0.01 mg/kg, and ketamine 0.5 mg/kg (group PK) diluted into a 5 ml solution, followed 3 minutes later by cisatracurium 0.15 mg/kg in group C and K, and 0.14 mg/kg cisatracurium in priming group. Onset time was recorded the electromyographical responses using single twitch and intubating conditions were evaluated at 60 seconds after cisatracurium administration.ResultsThe mean onset time was most significantly accelerated in Group PK and was also significantly more accelerated in Group P and K compared with Group C (P < 0.008). It was 112.7 ± 13.2, 91.4 ± 17.9, 84.9 ± 12.7 and 76.4 ± 8.3 seconds in Group C, P, K, and PK, respectively. Intubating conditions were significantly improved in Group P, K and PK than Group C (P < 0.008). Especially, Group PK showed most significant improvement of intubating conditions.ConclusionsThe combination of the low dose ketamine and cisatracurium priming accelerated the onset time and was improved the intubating conditions.http://ekja.org/upload/pdf/kjae-63-308.pdfcisatracuriumintubationketamineonsetpriming |
| spellingShingle | Byung-Ryang Ahn Sang-Hun Kim Byung-Sik Yu Kyung-Joon Lim Jong-June Sun The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium Korean Journal of Anesthesiology cisatracurium intubation ketamine onset priming |
| title | The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium |
| title_full | The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium |
| title_fullStr | The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium |
| title_full_unstemmed | The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium |
| title_short | The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium |
| title_sort | effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium |
| topic | cisatracurium intubation ketamine onset priming |
| url | http://ekja.org/upload/pdf/kjae-63-308.pdf |
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