Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism
Abstract Glycolytic reprogramming is emerging as a hallmark of various cancers and a promising therapeutic target. Nanotechnology is revolutionizing the anti-tumor therapeutic approaches associated with glycolysis. Finely controlled chemical composition and nanostructure provide nanomaterials unique...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01740-y |
| _version_ | 1811198330134331392 |
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| author | Zhengying Gu Chengzhong Yu |
| author_facet | Zhengying Gu Chengzhong Yu |
| author_sort | Zhengying Gu |
| collection | DOAJ |
| description | Abstract Glycolytic reprogramming is emerging as a hallmark of various cancers and a promising therapeutic target. Nanotechnology is revolutionizing the anti-tumor therapeutic approaches associated with glycolysis. Finely controlled chemical composition and nanostructure provide nanomaterials unique advantages, enabling an excellent platform for integrated drug delivery, biochemical modulation and combination therapy. Recent studies have shown promising potential of nanotherapeutic strategies in modulating tumor glycolytic metabolism alone or in combination with other treatments such as chemotherapy, radiotherapy and immunotherapy. To foster more innovation in this cutting-edge and interdisciplinary field, this review summarizes recent understandings of the origin and development of tumor glycolysis, then provides the latest advances in how nanomaterials modulate tumor glycolysis-related metabolism. The interplay of nanochemistry, metabolism and immunity is highlighted. Ultimately, the challenges and opportunities are presented. |
| first_indexed | 2024-04-12T01:29:35Z |
| format | Article |
| id | doaj.art-641b03025d194c3aa0a29ac2855507a1 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-12T01:29:35Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-641b03025d194c3aa0a29ac2855507a12022-12-22T03:53:32ZengBMCJournal of Nanobiotechnology1477-31552022-12-0120111910.1186/s12951-022-01740-yHarnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolismZhengying Gu0Chengzhong Yu1School of Chemistry and Molecular Engineering, East China Normal UniversitySchool of Chemistry and Molecular Engineering, East China Normal UniversityAbstract Glycolytic reprogramming is emerging as a hallmark of various cancers and a promising therapeutic target. Nanotechnology is revolutionizing the anti-tumor therapeutic approaches associated with glycolysis. Finely controlled chemical composition and nanostructure provide nanomaterials unique advantages, enabling an excellent platform for integrated drug delivery, biochemical modulation and combination therapy. Recent studies have shown promising potential of nanotherapeutic strategies in modulating tumor glycolytic metabolism alone or in combination with other treatments such as chemotherapy, radiotherapy and immunotherapy. To foster more innovation in this cutting-edge and interdisciplinary field, this review summarizes recent understandings of the origin and development of tumor glycolysis, then provides the latest advances in how nanomaterials modulate tumor glycolysis-related metabolism. The interplay of nanochemistry, metabolism and immunity is highlighted. Ultimately, the challenges and opportunities are presented.https://doi.org/10.1186/s12951-022-01740-yBioactive nanomaterialsTumor metabolismGlycolysisTumor immunityCancer therapy |
| spellingShingle | Zhengying Gu Chengzhong Yu Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism Journal of Nanobiotechnology Bioactive nanomaterials Tumor metabolism Glycolysis Tumor immunity Cancer therapy |
| title | Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism |
| title_full | Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism |
| title_fullStr | Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism |
| title_full_unstemmed | Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism |
| title_short | Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism |
| title_sort | harnessing bioactive nanomaterials in modulating tumor glycolysis associated metabolism |
| topic | Bioactive nanomaterials Tumor metabolism Glycolysis Tumor immunity Cancer therapy |
| url | https://doi.org/10.1186/s12951-022-01740-y |
| work_keys_str_mv | AT zhengyinggu harnessingbioactivenanomaterialsinmodulatingtumorglycolysisassociatedmetabolism AT chengzhongyu harnessingbioactivenanomaterialsinmodulatingtumorglycolysisassociatedmetabolism |