Circulating and Adipose Tissue Adiponectin Level and Outcomes in Incident Peritoneal Dialysis PatientsPlain-Language Summary
Rationale & Objective: Cardiovascular disease is the major cause of mortality and morbidity in peritoneal dialysis (PD) patients. Adiponectin, a key adipokine, is related to obesity and insulin resistance. We determined the clinical and prognostic value of plasma adiponectin level and its ad...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Kidney Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059522002229 |
| _version_ | 1811154715719761920 |
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| author | Win Hlaing Than Gordon Chun-Kau Chan Bonnie Ching-Ha Kwan Ka-Bik Lai Ronald Cheong-Kin Chan Jeromy Yuen Chun Teoh Jack Kit-Chung Ng Winston Wing-Shing Fung Kai-Ming Chow Phyllis Mei-Shan Cheng Man-Ching Law Philip Kam-Tao Li Cheuk-Chun Szeto |
| author_facet | Win Hlaing Than Gordon Chun-Kau Chan Bonnie Ching-Ha Kwan Ka-Bik Lai Ronald Cheong-Kin Chan Jeromy Yuen Chun Teoh Jack Kit-Chung Ng Winston Wing-Shing Fung Kai-Ming Chow Phyllis Mei-Shan Cheng Man-Ching Law Philip Kam-Tao Li Cheuk-Chun Szeto |
| author_sort | Win Hlaing Than |
| collection | DOAJ |
| description | Rationale & Objective: Cardiovascular disease is the major cause of mortality and morbidity in peritoneal dialysis (PD) patients. Adiponectin, a key adipokine, is related to obesity and insulin resistance. We determined the clinical and prognostic value of plasma adiponectin level and its adipose tissue messenger RNA (mRNA) expression in new PD patients. Study Design: Retrospective analysis of a prospective observational study. Setting & Participants: 152 new PD patients from a single center; 6 adults undergoing abdominal surgeries without kidney disease served as controls. Predictors: Plasma adiponectin level and its adipose tissue mRNA expression. Outcomes: Body build and composition, patient and technique survival. Analytical Approach: Adiponectin level and mRNA expression were grouped in quartiles for correlation analysis for body build and Cox regression for survival analysis. Results: The median plasma adiponectin level was 31.98 μg/mL (IQR, 16.81-49.49 μg/mL), and adiponectin mRNA expression in adipose tissue was 1.65 times higher than in controls (IQR, 0.98-2.63). There was a modest but statistically significant correlation between plasma adiponectin and its adipose tissue mRNA expression (r = 0.40, P < 0.001). Plasma adiponectin level inversely correlated with body mass index, waist-hip ratio, mid-arm circumference, adipose tissue mass, plasma triglyceride (r = -0.39, -0.38, -0.41, -0.38, and -0.30, respectively; P < 0.001 for all), as well as serum insulin level (r = -0.24, P = 0.005). Similar correlations were present but less marked with adipose tissue adiponectin mRNA level. Neither plasma adiponectin level nor adipose tissue adiponectin mRNA level predicted patient or technique survival. Limitations: Observational study, single center, single baseline measurement. Conclusions: Plasma adiponectin level correlated with the degree of adiposity in new PD patients. However, neither plasma adiponectin level nor its adipose tissue mRNA expression was an independent prognostic indicator in kidney failure patients newly started on PD. |
| first_indexed | 2024-04-10T04:20:38Z |
| format | Article |
| id | doaj.art-6420941214864f9eafb96ca897946f9a |
| institution | Directory Open Access Journal |
| issn | 2590-0595 |
| language | English |
| last_indexed | 2024-04-10T04:20:38Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj.art-6420941214864f9eafb96ca897946f9a2023-03-11T04:20:21ZengElsevierKidney Medicine2590-05952023-03-0153100589Circulating and Adipose Tissue Adiponectin Level and Outcomes in Incident Peritoneal Dialysis PatientsPlain-Language SummaryWin Hlaing Than0Gordon Chun-Kau Chan1Bonnie Ching-Ha Kwan2Ka-Bik Lai3Ronald Cheong-Kin Chan4Jeromy Yuen Chun Teoh5Jack Kit-Chung Ng6Winston Wing-Shing Fung7Kai-Ming Chow8Phyllis Mei-Shan Cheng9Man-Ching Law10Philip Kam-Tao Li11Cheuk-Chun Szeto12Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Li Ka Shing Institute of Health Sciences (LiHS), Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaDepartment of Anatomical & Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaDepartment of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Li Ka Shing Institute of Health Sciences (LiHS), Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Address for Correspondence: Cheuk-Chun Szeto, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.Rationale & Objective: Cardiovascular disease is the major cause of mortality and morbidity in peritoneal dialysis (PD) patients. Adiponectin, a key adipokine, is related to obesity and insulin resistance. We determined the clinical and prognostic value of plasma adiponectin level and its adipose tissue messenger RNA (mRNA) expression in new PD patients. Study Design: Retrospective analysis of a prospective observational study. Setting & Participants: 152 new PD patients from a single center; 6 adults undergoing abdominal surgeries without kidney disease served as controls. Predictors: Plasma adiponectin level and its adipose tissue mRNA expression. Outcomes: Body build and composition, patient and technique survival. Analytical Approach: Adiponectin level and mRNA expression were grouped in quartiles for correlation analysis for body build and Cox regression for survival analysis. Results: The median plasma adiponectin level was 31.98 μg/mL (IQR, 16.81-49.49 μg/mL), and adiponectin mRNA expression in adipose tissue was 1.65 times higher than in controls (IQR, 0.98-2.63). There was a modest but statistically significant correlation between plasma adiponectin and its adipose tissue mRNA expression (r = 0.40, P < 0.001). Plasma adiponectin level inversely correlated with body mass index, waist-hip ratio, mid-arm circumference, adipose tissue mass, plasma triglyceride (r = -0.39, -0.38, -0.41, -0.38, and -0.30, respectively; P < 0.001 for all), as well as serum insulin level (r = -0.24, P = 0.005). Similar correlations were present but less marked with adipose tissue adiponectin mRNA level. Neither plasma adiponectin level nor adipose tissue adiponectin mRNA level predicted patient or technique survival. Limitations: Observational study, single center, single baseline measurement. Conclusions: Plasma adiponectin level correlated with the degree of adiposity in new PD patients. However, neither plasma adiponectin level nor its adipose tissue mRNA expression was an independent prognostic indicator in kidney failure patients newly started on PD.http://www.sciencedirect.com/science/article/pii/S2590059522002229Adiponectinadiposeoutcomeperitoneal dialysisplasma |
| spellingShingle | Win Hlaing Than Gordon Chun-Kau Chan Bonnie Ching-Ha Kwan Ka-Bik Lai Ronald Cheong-Kin Chan Jeromy Yuen Chun Teoh Jack Kit-Chung Ng Winston Wing-Shing Fung Kai-Ming Chow Phyllis Mei-Shan Cheng Man-Ching Law Philip Kam-Tao Li Cheuk-Chun Szeto Circulating and Adipose Tissue Adiponectin Level and Outcomes in Incident Peritoneal Dialysis PatientsPlain-Language Summary Kidney Medicine Adiponectin adipose outcome peritoneal dialysis plasma |
| title | Circulating and Adipose Tissue Adiponectin Level and Outcomes in Incident Peritoneal Dialysis PatientsPlain-Language Summary |
| title_full | Circulating and Adipose Tissue Adiponectin Level and Outcomes in Incident Peritoneal Dialysis PatientsPlain-Language Summary |
| title_fullStr | Circulating and Adipose Tissue Adiponectin Level and Outcomes in Incident Peritoneal Dialysis PatientsPlain-Language Summary |
| title_full_unstemmed | Circulating and Adipose Tissue Adiponectin Level and Outcomes in Incident Peritoneal Dialysis PatientsPlain-Language Summary |
| title_short | Circulating and Adipose Tissue Adiponectin Level and Outcomes in Incident Peritoneal Dialysis PatientsPlain-Language Summary |
| title_sort | circulating and adipose tissue adiponectin level and outcomes in incident peritoneal dialysis patientsplain language summary |
| topic | Adiponectin adipose outcome peritoneal dialysis plasma |
| url | http://www.sciencedirect.com/science/article/pii/S2590059522002229 |
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