A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria
ABSTRACTNatural products and their derivatives historically represent alternatives to conventional synthetic molecules for pharmacotherapy, ranging from cancer chemotherapeutics to cosmetic ingredients that exert anti-aging activities. Cellular senescence is considered a main driver of skin aging, y...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-11-01
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| Series: | Animal Cells and Systems |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19768354.2022.2143895 |
| _version_ | 1797815435863785472 |
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| author | Eun-Jung Kim Jieun Woo Seoungwoo Shin HaeBeen Choi Youngseok Kim Junoh Kim Chanhee Kang |
| author_facet | Eun-Jung Kim Jieun Woo Seoungwoo Shin HaeBeen Choi Youngseok Kim Junoh Kim Chanhee Kang |
| author_sort | Eun-Jung Kim |
| collection | DOAJ |
| description | ABSTRACTNatural products and their derivatives historically represent alternatives to conventional synthetic molecules for pharmacotherapy, ranging from cancer chemotherapeutics to cosmetic ingredients that exert anti-aging activities. Cellular senescence is considered a main driver of skin aging, yet natural products that target skin senescence in a specific manner are not thoroughly explored. Here, we performed a focused compound screen to identify natural products that exert anti-senescence effects. We found that Isatis tinctoria, woad extracts, displayed a senolytic effect on senescent human skin fibroblasts. Furthermore, treatment with woad extracts attenuated the expression of pro-inflammatory senescence-associated secretory phenotype (SASP), showing a senostatic activity. Intriguingly, woad extracts displayed only a marginal cytotoxic effect toward senescent human lung fibroblasts. Thus, our results reveal the potential activities of woad extracts for targeting skin senescence and suggest that woad extracts could be an attractive ingredient for cosmetics to prevent skin aging. |
| first_indexed | 2024-03-13T08:22:40Z |
| format | Article |
| id | doaj.art-642133b096614e81a37fecaca57f1f10 |
| institution | Directory Open Access Journal |
| issn | 1976-8354 2151-2485 |
| language | English |
| last_indexed | 2024-03-13T08:22:40Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj.art-642133b096614e81a37fecaca57f1f102023-05-31T05:33:12ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852022-11-0126631031710.1080/19768354.2022.2143895A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoriaEun-Jung Kim0Jieun Woo1Seoungwoo Shin2HaeBeen Choi3Youngseok Kim4Junoh Kim5Chanhee Kang6School of Biological Sciences, Seoul National University, Seoul, South KoreaBiospectrum, Biospectrum Life Science Institute, Yongin, South KoreaBiospectrum, Biospectrum Life Science Institute, Yongin, South KoreaSchool of Biological Sciences, Seoul National University, Seoul, South KoreaShinsegae International Inc., Seoul, South KoreaShinsegae International Inc., Seoul, South KoreaSchool of Biological Sciences, Seoul National University, Seoul, South KoreaABSTRACTNatural products and their derivatives historically represent alternatives to conventional synthetic molecules for pharmacotherapy, ranging from cancer chemotherapeutics to cosmetic ingredients that exert anti-aging activities. Cellular senescence is considered a main driver of skin aging, yet natural products that target skin senescence in a specific manner are not thoroughly explored. Here, we performed a focused compound screen to identify natural products that exert anti-senescence effects. We found that Isatis tinctoria, woad extracts, displayed a senolytic effect on senescent human skin fibroblasts. Furthermore, treatment with woad extracts attenuated the expression of pro-inflammatory senescence-associated secretory phenotype (SASP), showing a senostatic activity. Intriguingly, woad extracts displayed only a marginal cytotoxic effect toward senescent human lung fibroblasts. Thus, our results reveal the potential activities of woad extracts for targeting skin senescence and suggest that woad extracts could be an attractive ingredient for cosmetics to prevent skin aging.https://www.tandfonline.com/doi/10.1080/19768354.2022.2143895Cellular senescencesenolyticssenostaticsI. tinctoriaskin aging |
| spellingShingle | Eun-Jung Kim Jieun Woo Seoungwoo Shin HaeBeen Choi Youngseok Kim Junoh Kim Chanhee Kang A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria Animal Cells and Systems Cellular senescence senolytics senostatics I. tinctoria skin aging |
| title | A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria |
| title_full | A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria |
| title_fullStr | A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria |
| title_full_unstemmed | A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria |
| title_short | A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria |
| title_sort | focused natural compound screen reveals senolytic and senostatic effects of isatis tinctoria |
| topic | Cellular senescence senolytics senostatics I. tinctoria skin aging |
| url | https://www.tandfonline.com/doi/10.1080/19768354.2022.2143895 |
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