Apply a Physiologically Based Pharmacokinetic Model to Promote the Development of Enrofloxacin Granules: Predict Withdrawal Interval and Toxicity Dose

Apply a Physiologically Based Pharmacokinetic Model to Promote the Development of Enrofloxacin Granules: Predict Withdrawal Interval and Toxicity Dose

Enrofloxacin (ENR) granules were developed to prevent and control the infections caused by foodborne zoonotic intestinal pathogens in our previous studies. To promote the further development of ENR granules and standardize their usage in pigs, a physiologically based pharmacokinetic (PBPK) model of...

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Bibliographic Details
Main Authors: Kaixiang Zhou, Aimei Liu, Wenjin Ma, Lei Sun, Kun Mi, Xiangyue Xu, Samah Attia Algharib, Shuyu Xie, Lingli Huang
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antibiotics
Subjects:
enrofloxacin
physiologically based pharmacokinetic model
residue
liver toxicity
development of antibiotic
Online Access:https://www.mdpi.com/2079-6382/10/8/955

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