More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series)
Advances in tissue fixation and imaging techniques have yielded increasing appreciation for the glycosaminoglycan-rich endothelial glycocalyx and its in vivo manifestation, the endothelial surface layer (ESL). Pathological loss of the ESL during critical illness promotes local endothelial dysfunctio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-12-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045893217745786 |
| _version_ | 1828196618152706048 |
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| author | Kaori Oshima Sarah M. Haeger Joseph A. Hippensteel Paco S. Herson Eric P. Schmidt |
| author_facet | Kaori Oshima Sarah M. Haeger Joseph A. Hippensteel Paco S. Herson Eric P. Schmidt |
| author_sort | Kaori Oshima |
| collection | DOAJ |
| description | Advances in tissue fixation and imaging techniques have yielded increasing appreciation for the glycosaminoglycan-rich endothelial glycocalyx and its in vivo manifestation, the endothelial surface layer (ESL). Pathological loss of the ESL during critical illness promotes local endothelial dysfunction and, consequently, organ injury. Glycosaminoglycan fragments, such as heparan sulfate, are released into the plasma of animals and humans after ESL degradation and have thus served as a biomarker of endothelial injury. The development of state-of-the-art glycomic techniques, however, has revealed that these circulating heparan sulfate fragments are capable of influencing growth factor and other signaling pathways distant to the site of ESL injury. This review summarizes the current state of knowledge concerning the local (i.e. endothelial injury) and systemic (i.e. para- or endocrine) consequences of ESL degradation and identifies opportunities for future, novel investigations. |
| first_indexed | 2024-04-12T10:05:15Z |
| format | Article |
| id | doaj.art-6425722f28e846cda5813d0aa000190c |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-04-12T10:05:15Z |
| publishDate | 2017-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-6425722f28e846cda5813d0aa000190c2022-12-22T03:37:27ZengWileyPulmonary Circulation2045-89402017-12-01810.1177/2045893217745786More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series)Kaori OshimaSarah M. HaegerJoseph A. HippensteelPaco S. HersonEric P. Schmidt0Department of Medicine, Denver Health Medical Center, Denver, CO, USAAdvances in tissue fixation and imaging techniques have yielded increasing appreciation for the glycosaminoglycan-rich endothelial glycocalyx and its in vivo manifestation, the endothelial surface layer (ESL). Pathological loss of the ESL during critical illness promotes local endothelial dysfunction and, consequently, organ injury. Glycosaminoglycan fragments, such as heparan sulfate, are released into the plasma of animals and humans after ESL degradation and have thus served as a biomarker of endothelial injury. The development of state-of-the-art glycomic techniques, however, has revealed that these circulating heparan sulfate fragments are capable of influencing growth factor and other signaling pathways distant to the site of ESL injury. This review summarizes the current state of knowledge concerning the local (i.e. endothelial injury) and systemic (i.e. para- or endocrine) consequences of ESL degradation and identifies opportunities for future, novel investigations.https://doi.org/10.1177/2045893217745786 |
| spellingShingle | Kaori Oshima Sarah M. Haeger Joseph A. Hippensteel Paco S. Herson Eric P. Schmidt More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series) Pulmonary Circulation |
| title | More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series) |
| title_full | More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series) |
| title_fullStr | More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series) |
| title_full_unstemmed | More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series) |
| title_short | More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series) |
| title_sort | more than a biomarker the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation 2017 grover conference series |
| url | https://doi.org/10.1177/2045893217745786 |
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