Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit
ObjectivesTo determine vitamin C plasma kinetics, through the measurement of vitamin C plasma concentrations, in critically ill Coronavirus infectious disease 2019 (COVID-19) patients, identifying eventually the onset of vitamin C deficiency.DesignProspective, observational, single-center study.Sett...
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Frontiers Media S.A.
2023-12-01
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Series: | Frontiers in Medicine |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1301001/full |
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author | Luis Chiscano-Camón Luis Chiscano-Camón Luis Chiscano-Camón Juan Carlos Ruiz-Rodriguez Juan Carlos Ruiz-Rodriguez Juan Carlos Ruiz-Rodriguez Erika P. Plata-Menchaca Erika P. Plata-Menchaca Laura Martin Laura Martin Ivan Bajaña Ivan Bajaña Cristina Martin-Rodríguez Cristina Martin-Rodríguez Clara Palmada Clara Palmada Roser Ferrer-Costa Silvia Camos Yolanda Villena-Ortiz Vicent Ribas Adolf Ruiz-Sanmartin Adolf Ruiz-Sanmartin Marcos Pérez-Carrasco Marcos Pérez-Carrasco Ricard Ferrer Ricard Ferrer Ricard Ferrer Ricard Ferrer |
author_facet | Luis Chiscano-Camón Luis Chiscano-Camón Luis Chiscano-Camón Juan Carlos Ruiz-Rodriguez Juan Carlos Ruiz-Rodriguez Juan Carlos Ruiz-Rodriguez Erika P. Plata-Menchaca Erika P. Plata-Menchaca Laura Martin Laura Martin Ivan Bajaña Ivan Bajaña Cristina Martin-Rodríguez Cristina Martin-Rodríguez Clara Palmada Clara Palmada Roser Ferrer-Costa Silvia Camos Yolanda Villena-Ortiz Vicent Ribas Adolf Ruiz-Sanmartin Adolf Ruiz-Sanmartin Marcos Pérez-Carrasco Marcos Pérez-Carrasco Ricard Ferrer Ricard Ferrer Ricard Ferrer Ricard Ferrer |
author_sort | Luis Chiscano-Camón |
collection | DOAJ |
description | ObjectivesTo determine vitamin C plasma kinetics, through the measurement of vitamin C plasma concentrations, in critically ill Coronavirus infectious disease 2019 (COVID-19) patients, identifying eventually the onset of vitamin C deficiency.DesignProspective, observational, single-center study.SettingIntensive Care Unit (ICU), Vall d’Hebron University Hospital, Barcelona. Study period from November 12th, 2020, to February 24th, 2021.PatientsPatients who had a severe hypoxemic acute respiratory failure due to COVID-19 were included.InterventionsPlasma vitamin C concentrations were measured on days 1, 5, and 10 of ICU admission. There were no vitamin C enteral nor parenteral supplementation. The supportive treatment was performed following the standard of care or acute respiratory distress syndrome (ARDS) patients.MeasurementPlasma vitamin C concentrations were analyzed using an ultra-performance liquid chromatography (UPLC) system with a photodiode array detector (wavelength set to 245 nm). We categorized plasmatic levels of vitamin C as follows: undetectable: < 1,5 mg/L, deficiency: <2 mg/L. Low plasma concentrations: 2–5 mg/L; (normal plasma concentration: > 5 mg/L).Main resultsForty-three patients were included (65% men; mean age 62 ± 10 years). The median Sequential Organ Failure Assessment (SOFA) score was 3 (1–4), and the Acute Physiology and Chronic Health disease Classification System (APACHE II) score was 13 (10–22). Five patients had shock. Bacterial coinfection was documented in 7 patients (16%). Initially all patients required high-flow oxygen therapy, and 23 (53%) further needed invasive mechanical ventilation during 21 (± 10) days. The worst PaO2/FIO2 registered was 93 (± 29). ICU and hospital survival were 77 and 74%, respectively. Low or undetectable levels remained constant throughout the study period in the vast majority of patients.ConclusionThis observational study showed vitamin C plasma levels were undetectable on ICU admission in 86% of patients with acute respiratory failure due to COVID-19 pneumonia requiring respiratory support. This finding remained consistent throughout the study period. |
first_indexed | 2024-03-08T21:46:02Z |
format | Article |
id | doaj.art-6425b18952f44d85931c1541b90d93c6 |
institution | Directory Open Access Journal |
issn | 2296-858X |
language | English |
last_indexed | 2024-03-08T21:46:02Z |
publishDate | 2023-12-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Medicine |
spelling | doaj.art-6425b18952f44d85931c1541b90d93c62023-12-20T08:58:53ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-12-011010.3389/fmed.2023.13010011301001Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unitLuis Chiscano-Camón0Luis Chiscano-Camón1Luis Chiscano-Camón2Juan Carlos Ruiz-Rodriguez3Juan Carlos Ruiz-Rodriguez4Juan Carlos Ruiz-Rodriguez5Erika P. Plata-Menchaca6Erika P. Plata-Menchaca7Laura Martin8Laura Martin9Ivan Bajaña10Ivan Bajaña11Cristina Martin-Rodríguez12Cristina Martin-Rodríguez13Clara Palmada14Clara Palmada15Roser Ferrer-Costa16Silvia Camos17Yolanda Villena-Ortiz18Vicent Ribas19Adolf Ruiz-Sanmartin20Adolf Ruiz-Sanmartin21Marcos Pérez-Carrasco22Marcos Pérez-Carrasco23Ricard Ferrer24Ricard Ferrer25Ricard Ferrer26Ricard Ferrer27Intensive Care Department, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainDepartament de Medicina, Universitat Autonoma de Barcelona, Bellatera, SpainIntensive Care Department, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainDepartament de Medicina, Universitat Autonoma de Barcelona, Bellatera, SpainIntensive Care Department, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainClinical Biochemistry Service, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainClinical Biochemistry Laboratory, ICS-IAS Girona Clinical Laboratory, Doctor Josep Trueta University Hospital, Girona, SpainClinical Biochemistry Service, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainFundació Eurecat Centre Tecnològic de Catalunya, Catalonia, SpainIntensive Care Department, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainClinical Biochemistry Service, Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Barcelona, SpainCIBER Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Madrid, SpainObjectivesTo determine vitamin C plasma kinetics, through the measurement of vitamin C plasma concentrations, in critically ill Coronavirus infectious disease 2019 (COVID-19) patients, identifying eventually the onset of vitamin C deficiency.DesignProspective, observational, single-center study.SettingIntensive Care Unit (ICU), Vall d’Hebron University Hospital, Barcelona. Study period from November 12th, 2020, to February 24th, 2021.PatientsPatients who had a severe hypoxemic acute respiratory failure due to COVID-19 were included.InterventionsPlasma vitamin C concentrations were measured on days 1, 5, and 10 of ICU admission. There were no vitamin C enteral nor parenteral supplementation. The supportive treatment was performed following the standard of care or acute respiratory distress syndrome (ARDS) patients.MeasurementPlasma vitamin C concentrations were analyzed using an ultra-performance liquid chromatography (UPLC) system with a photodiode array detector (wavelength set to 245 nm). We categorized plasmatic levels of vitamin C as follows: undetectable: < 1,5 mg/L, deficiency: <2 mg/L. Low plasma concentrations: 2–5 mg/L; (normal plasma concentration: > 5 mg/L).Main resultsForty-three patients were included (65% men; mean age 62 ± 10 years). The median Sequential Organ Failure Assessment (SOFA) score was 3 (1–4), and the Acute Physiology and Chronic Health disease Classification System (APACHE II) score was 13 (10–22). Five patients had shock. Bacterial coinfection was documented in 7 patients (16%). Initially all patients required high-flow oxygen therapy, and 23 (53%) further needed invasive mechanical ventilation during 21 (± 10) days. The worst PaO2/FIO2 registered was 93 (± 29). ICU and hospital survival were 77 and 74%, respectively. Low or undetectable levels remained constant throughout the study period in the vast majority of patients.ConclusionThis observational study showed vitamin C plasma levels were undetectable on ICU admission in 86% of patients with acute respiratory failure due to COVID-19 pneumonia requiring respiratory support. This finding remained consistent throughout the study period.https://www.frontiersin.org/articles/10.3389/fmed.2023.1301001/fullSARS-CoV-2 pneumoniaacute respiratory distress syndromevitamin Cascorbic acidCOVID-19 |
spellingShingle | Luis Chiscano-Camón Luis Chiscano-Camón Luis Chiscano-Camón Juan Carlos Ruiz-Rodriguez Juan Carlos Ruiz-Rodriguez Juan Carlos Ruiz-Rodriguez Erika P. Plata-Menchaca Erika P. Plata-Menchaca Laura Martin Laura Martin Ivan Bajaña Ivan Bajaña Cristina Martin-Rodríguez Cristina Martin-Rodríguez Clara Palmada Clara Palmada Roser Ferrer-Costa Silvia Camos Yolanda Villena-Ortiz Vicent Ribas Adolf Ruiz-Sanmartin Adolf Ruiz-Sanmartin Marcos Pérez-Carrasco Marcos Pérez-Carrasco Ricard Ferrer Ricard Ferrer Ricard Ferrer Ricard Ferrer Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit Frontiers in Medicine SARS-CoV-2 pneumonia acute respiratory distress syndrome vitamin C ascorbic acid COVID-19 |
title | Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit |
title_full | Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit |
title_fullStr | Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit |
title_full_unstemmed | Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit |
title_short | Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit |
title_sort | vitamin c deficiency in critically ill covid 19 patients admitted to intensive care unit |
topic | SARS-CoV-2 pneumonia acute respiratory distress syndrome vitamin C ascorbic acid COVID-19 |
url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1301001/full |
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