Peripheral and Thymic Foxp3+ Regulatory T Cells in Search of Origin, Distinction and Function

Peripheral and Thymic Foxp3+ Regulatory T Cells in Search of Origin, Distinction and Function

Over the past decade, much has been learnt and much more to discover about Foxp3+ regulatory T cells (Tregs). Initially, it was thought that Tregs were a unique entity that originates in the thymus. It is now recognized that there is a fraternal twin sibling that is generated in the periphery. The d...

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Bibliographic Details
Main Authors: Chetan eDhamne, Yeonseok eChung, Amin Majid Alousi, Laurence J.N. Cooper, Dat Quoc Tran
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
Foxp3
regulatory T cells
immunological tolerance
Tregs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00253/full

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