Formulation of Bioerodible Ketamine Microparticles as an Analgesic Adjuvant Treatment Produced by Supercritical Fluid Polymer Encapsulation

Formulation of Bioerodible Ketamine Microparticles as an Analgesic Adjuvant Treatment Produced by Supercritical Fluid Polymer Encapsulation

Pain is inadequately relieved by escalating doses of a strong opioid analgesic such as morphine in up to 25% of patients with cancer-related severe pain complicated by a neuropathic (nerve damage) component. Hence, there is an unmet medical need for research on novel painkiller strategies. In the pr...

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Bibliographic Details
Main Authors: Felicity Y. Han, Andrew K. Whittaker, Steven M. Howdle, Andrew Naylor, Anjumn Shabir-Ahmed, Cheng Zhang, Maree T. Smith
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Pharmaceutics
Subjects:
analgesic adjuvant
ketamine
cancer pain
drug delivery
poly(lactic-<i>co</i>-glycolic acid) (PLGA)
sustained release
Online Access:https://www.mdpi.com/1999-4923/10/4/264

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