Comparison of various renal function assessment methods in patients with arterial hypertension
Aim. To evaluate the role of calculated glomerular filtration rate (GFR), microalbuminuria (MAU) and cystatin С assessment in renal pathology diagnostics among patients with arterial hypertension (AH) and normal or mildly elevated serum creatinine level.Material and methods. In 114 non-diabetic pati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2008-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1548 |
| Summary: | Aim. To evaluate the role of calculated glomerular filtration rate (GFR), microalbuminuria (MAU) and cystatin С assessment in renal pathology diagnostics among patients with arterial hypertension (AH) and normal or mildly elevated serum creatinine level.Material and methods. In 114 non-diabetic patients with non-treated AH (age 53,0+1,0 years, creatinine 94,3+1,7 mkmol/1) and 158 patients with AH and diabetes mellitus, DM (age 56,2+0,7 years, creatinine 81,6+1,2 mkmol/1), serum creatinine, MAU by albumin/urine creatinine ratio, and calculated GFR by Cockroft-Gault and MDRD formulas (GFRl, GFR2) were assessed. In patients with AH and DM, cystatin С level was also measured.Results. Among non-diabetic AH patients with normal creatinine level, decreased GFR2<60 ml/min/1,73 m2 but no GFRl reduction <60 ml/min/1,73 m2 was observed in 18,8%. MAU was registered in 7 non-diabetic AH patients (6,1%); in one participant, MAU was combined with decreased GFR2<60 ml/min/1,73 m2. Based on serum creatinine, MAU and GFR2 or GFRl measurement, subclinical renal pathology was diagnosed in 42,1% or 21,9% non-diabetic AH participants, respectively. Among subjects with AH and DM, MAU was observed in 12 (7,6%); in all patients with MAU creatinine level was normal; in 2 patients GFR2 was reduced <60 ml/mini,73 m2. In AH + DM group, cystatin С level was inversely related to GFR2 (r=-0,72; p<0,001), but not to GFRl.Conclusion. Combined measurement of serum creatinine, MAU and GFR levels improves the diagnostics of subclinical renal pathology in AH patients. In patients with AH and DM, cystatin С is sensitive to early renal dysfunction. |
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| ISSN: | 1728-8800 2619-0125 |