Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment
Multi-modal therapeutics are emerging for simultaneous diagnosis and treatment of cancer. Polymeric carriers are often employed for loading multiple drugs due to their versatility and controlled release of these drugs in response to a tumor specific microenvironment. A theranostic nanomedicine was d...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Acta Pharmaceutica Sinica B |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383520306687 |
| _version_ | 1818392117266874368 |
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| author | Hao Cai Yufan Xiang Yujun Zeng Zhiqian Li Xiuli Zheng Qiang Luo Hongyan Zhu Qiyong Gong Zhongwei Gu Yanhui Liu Hu Zhang Kui Luo |
| author_facet | Hao Cai Yufan Xiang Yujun Zeng Zhiqian Li Xiuli Zheng Qiang Luo Hongyan Zhu Qiyong Gong Zhongwei Gu Yanhui Liu Hu Zhang Kui Luo |
| author_sort | Hao Cai |
| collection | DOAJ |
| description | Multi-modal therapeutics are emerging for simultaneous diagnosis and treatment of cancer. Polymeric carriers are often employed for loading multiple drugs due to their versatility and controlled release of these drugs in response to a tumor specific microenvironment. A theranostic nanomedicine was designed and prepared by complexing a small gadolinium chelate, conjugating a chemotherapeutic drug PTX through a cathepsin B-responsive linker and covalently bonding a fluorescent probe pheophorbide a (Ppa) with a branched glycopolymer. The branched prodrug-based nanosystem was degradable in the tumor microenvironment with overexpressed cathepsin B, and PTX was simultaneously released to exert its therapeutic effect. The theranostic nanomedicine, branched glycopolymer-PTX-DOTA-Gd, had an extended circulation time, enhanced accumulation in tumors, and excellent biocompatibility with significantly reduced gadolinium ion (Gd3+) retention after 96 h post-injection. Enhanced imaging contrast up to 24 h post-injection and excellent antitumor efficacy with a tumor inhibition rate more than 90% were achieved from glycopolymer-PTX-DOTA-Gd without obvious systematic toxicity. This branched polymeric prodrug-based nanomedicine is very promising for safe and effective diagnosis and treatment of cancer. |
| first_indexed | 2024-12-14T05:24:19Z |
| format | Article |
| id | doaj.art-642c708fc72d4868912c701873a393f7 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-12-14T05:24:19Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-642c708fc72d4868912c701873a393f72022-12-21T23:15:34ZengElsevierActa Pharmaceutica Sinica B2211-38352021-02-01112544559Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatmentHao Cai0Yufan Xiang1Yujun Zeng2Zhiqian Li3Xiuli Zheng4Qiang Luo5Hongyan Zhu6Qiyong Gong7Zhongwei Gu8Yanhui Liu9Hu Zhang10Kui Luo11Huaxi MR Research Center (HMRRC), Department of Neurosurgery, and Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, ChinaHuaxi MR Research Center (HMRRC), Department of Neurosurgery, and Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, ChinaHuaxi MR Research Center (HMRRC), Department of Neurosurgery, and Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, ChinaHuaxi MR Research Center (HMRRC), Department of Neurosurgery, and Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, ChinaHuaxi MR Research Center (HMRRC), Department of Neurosurgery, and Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, ChinaHuaxi MR Research Center (HMRRC), Department of Neurosurgery, and Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, ChinaLaboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu 610041, ChinaHuaxi MR Research Center (HMRRC), Department of Neurosurgery, and Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, ChinaHuaxi MR Research Center (HMRRC), Department of Neurosurgery, and Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, ChinaHuaxi MR Research Center (HMRRC), Department of Neurosurgery, and Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors. Tel./fax: +86 28 85422538 (Kui Luo); +86 28 85423622 (Yanhui Liu).Amgen Bioprocessing Centre, Keck Graduate Institute, Claremont, CA 91711, USAHuaxi MR Research Center (HMRRC), Department of Neurosurgery, and Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors. Tel./fax: +86 28 85422538 (Kui Luo); +86 28 85423622 (Yanhui Liu).Multi-modal therapeutics are emerging for simultaneous diagnosis and treatment of cancer. Polymeric carriers are often employed for loading multiple drugs due to their versatility and controlled release of these drugs in response to a tumor specific microenvironment. A theranostic nanomedicine was designed and prepared by complexing a small gadolinium chelate, conjugating a chemotherapeutic drug PTX through a cathepsin B-responsive linker and covalently bonding a fluorescent probe pheophorbide a (Ppa) with a branched glycopolymer. The branched prodrug-based nanosystem was degradable in the tumor microenvironment with overexpressed cathepsin B, and PTX was simultaneously released to exert its therapeutic effect. The theranostic nanomedicine, branched glycopolymer-PTX-DOTA-Gd, had an extended circulation time, enhanced accumulation in tumors, and excellent biocompatibility with significantly reduced gadolinium ion (Gd3+) retention after 96 h post-injection. Enhanced imaging contrast up to 24 h post-injection and excellent antitumor efficacy with a tumor inhibition rate more than 90% were achieved from glycopolymer-PTX-DOTA-Gd without obvious systematic toxicity. This branched polymeric prodrug-based nanomedicine is very promising for safe and effective diagnosis and treatment of cancer.http://www.sciencedirect.com/science/article/pii/S2211383520306687Stimuli-responsiveDrug deliveryBranched glycopolymersBiodegradabilityNanomedicineTheranostics |
| spellingShingle | Hao Cai Yufan Xiang Yujun Zeng Zhiqian Li Xiuli Zheng Qiang Luo Hongyan Zhu Qiyong Gong Zhongwei Gu Yanhui Liu Hu Zhang Kui Luo Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment Acta Pharmaceutica Sinica B Stimuli-responsive Drug delivery Branched glycopolymers Biodegradability Nanomedicine Theranostics |
| title | Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment |
| title_full | Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment |
| title_fullStr | Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment |
| title_full_unstemmed | Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment |
| title_short | Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment |
| title_sort | cathepsin b responsive and gadolinium labeled branched glycopolymer ptx conjugate derived nanotheranostics for cancer treatment |
| topic | Stimuli-responsive Drug delivery Branched glycopolymers Biodegradability Nanomedicine Theranostics |
| url | http://www.sciencedirect.com/science/article/pii/S2211383520306687 |
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