Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp
The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 plays a pivotal role in the life cycle of the novel coronavirus and stands as a significant and promising target for anti-SARS-CoV-2 drugs. Non-nucleoside inhibitors (NNIs), as a category of compounds directed against SARS-CoV-2 RdRp, exhibit a u...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224000611 |
| _version_ | 1797324336221126656 |
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| author | Bangdi Zhou Dianming Chen Tingyan Zhang Chenggui Song Xianwu Zhang Leying Lin Jiuzhong Huang Xiaopeng Peng Yuanchang Liu Gaorong Wu Jingyuan Li Weiming Chen |
| author_facet | Bangdi Zhou Dianming Chen Tingyan Zhang Chenggui Song Xianwu Zhang Leying Lin Jiuzhong Huang Xiaopeng Peng Yuanchang Liu Gaorong Wu Jingyuan Li Weiming Chen |
| author_sort | Bangdi Zhou |
| collection | DOAJ |
| description | The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 plays a pivotal role in the life cycle of the novel coronavirus and stands as a significant and promising target for anti-SARS-CoV-2 drugs. Non-nucleoside inhibitors (NNIs), as a category of compounds directed against SARS-CoV-2 RdRp, exhibit a unique and highly effective mechanism, effectively overcoming various factors contributing to drug resistance against nucleoside inhibitors (NIs). This review investigates various NNIs, including both natural and synthetic inhibitors, that closely interacting with the SARS-CoV-2 RdRp with valid evidences from in vitro and in silico studies. |
| first_indexed | 2024-03-08T05:54:40Z |
| format | Article |
| id | doaj.art-642d6e4377464b9ca4b2faf7a1d21daf |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T05:54:40Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-642d6e4377464b9ca4b2faf7a1d21daf2024-02-05T04:31:24ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-02-01171116180Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRpBangdi Zhou0Dianming Chen1Tingyan Zhang2Chenggui Song3Xianwu Zhang4Leying Lin5Jiuzhong Huang6Xiaopeng Peng7Yuanchang Liu8Gaorong Wu9Jingyuan Li10Weiming Chen11Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou 341000, PR China; The First School of Clinical Medicine, Gannan Medical University, Ganzhou 341000, PR ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou 341000, PR China; School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, PR ChinaSchool of Nusing, Gannan Medical University, Ganzhou 341000, PR ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou 341000, PR ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou 341000, PR ChinaSchool of Basic Medicine, Gannan Medical University, Ganzhou 341000, PR ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou 341000, PR China; School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, PR ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou 341000, PR China; School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, PR ChinaSchool of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, PR ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou 341000, PR China; School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, PR ChinaSchool of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, PR ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou 341000, PR China; School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, PR China; Corresponding author at: School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, PR China.The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 plays a pivotal role in the life cycle of the novel coronavirus and stands as a significant and promising target for anti-SARS-CoV-2 drugs. Non-nucleoside inhibitors (NNIs), as a category of compounds directed against SARS-CoV-2 RdRp, exhibit a unique and highly effective mechanism, effectively overcoming various factors contributing to drug resistance against nucleoside inhibitors (NIs). This review investigates various NNIs, including both natural and synthetic inhibitors, that closely interacting with the SARS-CoV-2 RdRp with valid evidences from in vitro and in silico studies.http://www.sciencedirect.com/science/article/pii/S0753332224000611SARS-CoV-2RdRpNon-nucleoside inhibitorsNatural productsSynthetic inhibitors |
| spellingShingle | Bangdi Zhou Dianming Chen Tingyan Zhang Chenggui Song Xianwu Zhang Leying Lin Jiuzhong Huang Xiaopeng Peng Yuanchang Liu Gaorong Wu Jingyuan Li Weiming Chen Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp Biomedicine & Pharmacotherapy SARS-CoV-2 RdRp Non-nucleoside inhibitors Natural products Synthetic inhibitors |
| title | Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp |
| title_full | Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp |
| title_fullStr | Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp |
| title_full_unstemmed | Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp |
| title_short | Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp |
| title_sort | recent advancements in the discovery of small molecule non nucleoside inhibitors targeting sars cov 2 rdrp |
| topic | SARS-CoV-2 RdRp Non-nucleoside inhibitors Natural products Synthetic inhibitors |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224000611 |
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