Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp

Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp

The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 plays a pivotal role in the life cycle of the novel coronavirus and stands as a significant and promising target for anti-SARS-CoV-2 drugs. Non-nucleoside inhibitors (NNIs), as a category of compounds directed against SARS-CoV-2 RdRp, exhibit a u...

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Bibliographic Details
Main Authors: Bangdi Zhou, Dianming Chen, Tingyan Zhang, Chenggui Song, Xianwu Zhang, Leying Lin, Jiuzhong Huang, Xiaopeng Peng, Yuanchang Liu, Gaorong Wu, Jingyuan Li, Weiming Chen
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
SARS-CoV-2
RdRp
Non-nucleoside inhibitors
Natural products
Synthetic inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224000611

Internet

http://www.sciencedirect.com/science/article/pii/S0753332224000611

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