Molecular characterization of the endometrium as a fertility-determining factor
Background: Structural transformation of the endometrium during the menstrual cycle is a genetically determined process and is provided by complex molecular-biological interactions aimed at the onset and development of pregnancy. Sex steroid hormones play a key role in endometrial morphogenesis, whi...
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| Format: | Article |
| Language: | English |
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Scientific Medical Association of Moldova
2020-03-01
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| Series: | The Moldovan Medical Journal |
| Subjects: | |
| Online Access: | http://moldmedjournal.md/wp-content/uploads/2020/03/moldovan-med-j-2020-63-1-burac-et-al-full-text.pdf |
| _version_ | 1818850309908201472 |
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| author | Mihaela Burac Natalia Corolcova Valentin Friptu |
| author_facet | Mihaela Burac Natalia Corolcova Valentin Friptu |
| author_sort | Mihaela Burac |
| collection | DOAJ |
| description | Background: Structural transformation of the endometrium during the menstrual cycle is a genetically determined process and is provided by complex molecular-biological interactions aimed at the onset and development of pregnancy. Sex steroid hormones play a key role in endometrial morphogenesis, which mediate or directly affect angiogenesis and immunogenesis. Conclusions: The primary function of the endometrium is to provide an immuno-privileged site for embryo implantation and to provide a nurturing environment for the fetus during pregnancy. The cyclic differentiation of the endometrium depends on the actions of steroid hormones that act through specific down – stream mechanisms involving complex molecular signaling. The endometrium undergoes repetitive episodes of proliferation, secretion, and menstruation, up to 400 times during a woman’s life, without apparent signs of aging. The human endometrium undergoes complex and dynamic changes during the menstrual cycle. Thus, the combination of molecular, endocrine, biochemical, immunological factors leads to a complete transformation of the endometrium during the menstrual cycle. Secretory transformation of the endometrium with an appropriate ratio and distribution of estrogen and progesterone receptor expression, complete angiogenesis and immunological balance determine implantation, placentation and pregnancy development. |
| first_indexed | 2024-12-19T06:47:05Z |
| format | Article |
| id | doaj.art-642dcfa4e81648bba53fa84addf5a326 |
| institution | Directory Open Access Journal |
| issn | 2537-6373 2537-6381 |
| language | English |
| last_indexed | 2024-12-19T06:47:05Z |
| publishDate | 2020-03-01 |
| publisher | Scientific Medical Association of Moldova |
| record_format | Article |
| series | The Moldovan Medical Journal |
| spelling | doaj.art-642dcfa4e81648bba53fa84addf5a3262022-12-21T20:31:52ZengScientific Medical Association of MoldovaThe Moldovan Medical Journal2537-63732537-63812020-03-01631394310.5281/zenodo.3685660Molecular characterization of the endometrium as a fertility-determining factorMihaela Burac0https://orcid.org/0000-0002-1672-9467Natalia Corolcova1https://orcid.org/0000-0002-5155-2804Valentin Friptu2https://orcid.org/0000-0003-2804-899XNicolae Testemitsanu State University of Medicine and Pharmacy, Department of Gynecology, Obstetrics and Human Reproduction, Chisinau, the Republic of MoldovaNicolae Testemitsanu State University of Medicine and Pharmacy, Department of Gynecology, Obstetrics and Human Reproduction, Chisinau, the Republic of MoldovaNicolae Testemitsanu State University of Medicine and Pharmacy, Department of Gynecology, Obstetrics and Human Reproduction, Chisinau, the Republic of MoldovaBackground: Structural transformation of the endometrium during the menstrual cycle is a genetically determined process and is provided by complex molecular-biological interactions aimed at the onset and development of pregnancy. Sex steroid hormones play a key role in endometrial morphogenesis, which mediate or directly affect angiogenesis and immunogenesis. Conclusions: The primary function of the endometrium is to provide an immuno-privileged site for embryo implantation and to provide a nurturing environment for the fetus during pregnancy. The cyclic differentiation of the endometrium depends on the actions of steroid hormones that act through specific down – stream mechanisms involving complex molecular signaling. The endometrium undergoes repetitive episodes of proliferation, secretion, and menstruation, up to 400 times during a woman’s life, without apparent signs of aging. The human endometrium undergoes complex and dynamic changes during the menstrual cycle. Thus, the combination of molecular, endocrine, biochemical, immunological factors leads to a complete transformation of the endometrium during the menstrual cycle. Secretory transformation of the endometrium with an appropriate ratio and distribution of estrogen and progesterone receptor expression, complete angiogenesis and immunological balance determine implantation, placentation and pregnancy development.http://moldmedjournal.md/wp-content/uploads/2020/03/moldovan-med-j-2020-63-1-burac-et-al-full-text.pdfmenstrual cycleendometriumangiogenesisimmunogenesis |
| spellingShingle | Mihaela Burac Natalia Corolcova Valentin Friptu Molecular characterization of the endometrium as a fertility-determining factor The Moldovan Medical Journal menstrual cycle endometrium angiogenesis immunogenesis |
| title | Molecular characterization of the endometrium as a fertility-determining factor |
| title_full | Molecular characterization of the endometrium as a fertility-determining factor |
| title_fullStr | Molecular characterization of the endometrium as a fertility-determining factor |
| title_full_unstemmed | Molecular characterization of the endometrium as a fertility-determining factor |
| title_short | Molecular characterization of the endometrium as a fertility-determining factor |
| title_sort | molecular characterization of the endometrium as a fertility determining factor |
| topic | menstrual cycle endometrium angiogenesis immunogenesis |
| url | http://moldmedjournal.md/wp-content/uploads/2020/03/moldovan-med-j-2020-63-1-burac-et-al-full-text.pdf |
| work_keys_str_mv | AT mihaelaburac molecularcharacterizationoftheendometriumasafertilitydeterminingfactor AT nataliacorolcova molecularcharacterizationoftheendometriumasafertilitydeterminingfactor AT valentinfriptu molecularcharacterizationoftheendometriumasafertilitydeterminingfactor |